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关节腔注射益赛普治疗类风湿关节炎临床观察 被引量:7

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摘要 目的观察关节腔注射TNF-α拮抗剂益赛普对类风湿关节炎(rheumatoid arthritis,RA)的疗效。方法对60例单关节肿痛明显的RA患者进行关节腔注射益赛普,每次12.5mg,4周后观察临床指标。结果在关节腔注射后4周,患者在关节疼痛指数、关节压痛指数、关节肿胀指数、关节功能指数及关节僵硬指数较治疗前均有明显改善(P<0.01)。结论关节腔注射益赛普可以明显改善RA患者关节局部症状,操作简单易行,安全性好。
出处 《济宁医学院学报》 2013年第5期348-349,共2页 Journal of Jining Medical University
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  • 1邓小虎,黄烽.英夫利西单抗治疗炎性关节病的研究进展[J].中国药物应用与监测,2006,3(6):10-14. 被引量:17
  • 2MAIN1 R, ST CLAIR EW, BREEDVELD F, et al. Infliximab (chimeric anti-tumor necrosis factor alpha monoclonal antibody) versus placebo in rheumatoid arthritis patients receiving concomitant methotrexate: a randomized phase Ⅲ trial [J]. Lancet, 1999,354(9194) :1932 - 1939. 被引量:1
  • 3ST CLAI EW, VAN DER HEIJDE D, SMOLEN J, et al. Combi- nation of infliximab and methotrexate therapy for early rheumatoid arthritis: a randomized, controlled trial [ J]. Arthritis Rheum, 2004,50(11 ) :3432 -3443. 被引量:1
  • 4MAINI RN, BREEDVELD FC, KALDEN JR, et al. Therapeutic efficacy of multiple intravenous infusions of anti-tumor necrosis factor alpha monoclonal antibody combined with low-dose weekly methotrexate in rheumatoid arthritis[ J]. Arthritis Rheum, 1998, 41(9) :1552 - 1563. 被引量:1
  • 5LANGE U, TEICHMANN J, MULLE LADNER U, et at. Increase in bone mineral density of patients with rheumatoid arthritis treated with anti-TNF-antibody: a prospective open-label pilot study [ J ]. Rheumatology, 2005, 44 ( 12 ) : 1546 - 1548. 被引量:1
  • 6TARGAN SR, HANAUER SB, VAN DEVENTER SJH. A shortterm study of chimeric monoclonal antibody cA2 to tumor necrosis factor alpha for Corhn's disease[JJ. N Engl J Med, 1997,337 (15) :1029 - 1035. 被引量:1
  • 7HANAUER SB, FEAGAN BG, LICHTENSTIN GR,et al. Maintenance infiliximab for Crohn's disease: the ACCENT I randomized trial[J]. Lancet, 2002,359(9317) :1541 -1549. 被引量:1
  • 8PRESENT DH, RUTGEERTS P, TARGAN S, et al. Infliximab for the treatment of fistulas in patients with Crohn's disease[ J]. N Engl J Med, 1999,340 ( 18 ) : 1398 - 1405. 被引量:1
  • 9BRAUN J, BRANDT J, LISTING J, et al. Treatment of active ankylosing spondylitis with infliximab: a randomized controlled multicentre trial[ J ]. Lancet,2002,359 (9313 ) : 1187 - 1193. 被引量:1
  • 10VAN DEN BOSCH F, KRUITHOF E, BAETEN D, et al. Randomized double-bllnd comparison of chimeric monoclonal antibody to tumor necrosis factor alpha(infliximab) versus placebo in active spondylarthropathy [ J ]. Arthritis Rheum, 2002, 46 ( 3 ) : 755 -765. 被引量:1

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