摘要
目的探究与分析雷替曲塞与5-氟尿嘧啶毒副反应对比结果。方法 60例晚期结直肠癌患者采取随机数字表法分成试验组和对照组,试验组采用雷替曲塞进行治疗,对照组采用5-氟尿嘧啶进行治疗。观察并比较2组患者经不同治疗方式后的临床效果及毒副反应。结果试验组患者经治疗后的有效人数高于对照组36.67%(P<0.05)。试验组患者出现呕吐、神经毒性、脱发的人数较对照组明显减少,分别少26.67%、26.66%、26.66%(P<0.05)。结论雷替曲塞治疗方案更适于用晚期结直肠癌患者,具有高效低毒的优势,值得在临床范围内广泛推广。
Objective To discuss and study the toxicities of rahitrexed and 5-fluorouracil. Methods Sixty pa- tients with advanced colorectal cancer were divided into the experimental group and the control group according to random number table, the patients of the experimental group adopted raltitrexed, and the patients of the control group adopted 5-fluorouracil. The efficacy and toxicities of the two groups were compared. Results The effective number in the experimental group was higher than that of the control group （36.67%, P 〈0.05）. The number of patients who occurred vomit, neurovirulence and baldness in the experimental group were fewer than those of the control group, respectively （26.67%, 26.66% and 26.66%, P 〈 0.05 ）. Conclusion Raltitrexed is more suit- able for patients with advanced colorectal cancer, because it produces smaller toxicities, and has the good efficacy.
出处
《肿瘤基础与临床》
2013年第5期434-436,共3页
journal of basic and clinical oncology
