摘要
目的观察雷替曲塞联合奥沙利铂治疗晚期结直肠癌的临床效果。方法将我院收治的经病理组织学或细胞学检查证实为晚期(Ⅲ～Ⅳ)结直肠癌45例随机分为治疗组(21例)和对照组(24例)。治疗组采用雷替曲塞联合奥沙利铂方案化疗,对照组采用奥沙利铂联合氟尿嘧啶及亚叶酸钙方案化疗,观察并比较两组治疗效果、不良反应及生存情况。结果治疗组及对照组有效率分别为40.0%和13.0%,差异有统计学意义(P<0.05);中位疾病进展时间分别为8.6个月和5.3个月,中位生存期分别为10.8个月和9.4个月,Kaplan-Meier生存分析结果示其差异均有统计学意义(P<0.05)。对照组呕吐例数明显高于治疗组,差异有统计学意义(P<0.05)。结论晚期结直肠癌应用雷替曲塞联合奥沙利铂方案化疗效果优于奥沙利铂联合氟尿嘧啶及亚叶酸钙标准化疗方案,且不良反应少。
Objective To observe the clinical therapeutic effect of Raltitrexed plus Oxaliplatin for advanced colorectal cancer.Methods 45 patients diagnosed as having advanced colorectal cancer（Ⅲ~Ⅳ） by pathology or cytology in our hospital were randomly divided into treatment group（21 cases） and control group（24 cases）.Patients in the treatment group received Raltitrexed plus Oxaliplatin,while patients in the control group received Oxaliplatin plus Fluorouracil and Calcium folinate,treatment effectiveness,adverse reactions and survival times were observed and compared.Results The effective rates were 40.0% and 13.0% in the treatment group and the control group respectively,with significant difference between them（P0.05）.The median time to slow down progression（8.6 months vs.5.3 months）,the median overall survival time（10.8 months vs.9.4 months）,the Kaplan-Meier survival analysis result showed that there were statistically significant differences（P0.05）.The vomiting reaction was higher in the control group than in treatment group,and the differences were significant（P0.05）.Conclusion The clinical efficacy of Raltitrexed plus Fluorouracil and Calcium Folinate is better than Oxaliplatin plus Fluorouracil and Calcium Folinate for advanced colorectal cancer,with a lower rate of adverse reaction.
出处
《临床误诊误治》
2012年第2期43-46,共4页
Clinical Misdiagnosis & Mistherapy
