摘要
目的探讨皮肌炎(DM)合并恶性肿瘤的临床相关因素。方法回顾性分析2005年7月至2012年12月收治的283例DM患者临床资料,并对合并恶性肿瘤患者的肿瘤类型、临床表现、血清酶学指标和肿瘤标志物检测进行分析。结果 DM患者合并肿瘤发生率为12.4%,其中肺癌发病率最高为38.2%。DM合并肿瘤患者红细胞沉降率(ESR)、谷草转氨酶(AST)、肌酸激酶(CK)和乳酸脱氢酶(LDH)显著高于DM未合并恶性肿瘤患者(P<0.05或P<0.01);肿瘤标志物癌胚抗原(CEA)、甲胎蛋白(AFP)以及糖蛋白抗原(CA125、CA153和CA19-9)水平存在异常,其中肿瘤标记物CEA和CA125升高最常见。结论年龄>40岁、血清酶学指标ESR、AST、CK以及LDH等升高是DM并发恶性肿瘤的临床相关因素。
Objective To observe the clinical features of dermatomyositis （DM） with malignancy in Liaoning province. Methods The clinical data of 283 cases of DM patients from July 2005 to December 2012, were retrospectivly analysed, and the tumor type, clinical manifestations, serum enzyme indicators and tumor markers of DM with malignancy were detected. Results The rate of tumor incidence was 12.4% , and the incidence of lung cancer was up to 38.2%. The DM with malignantcy patients＇ enzymolo- gy indicators of erythrocyte sedimentation rate （ESR）, aspartate aminotransferase （AST）, creatine kinase （CK） and lactate dehydrogenase （LDH） were significantly higher than DM unconsolidated cancer patients （ P 〈 0. 05 or P 〈 0. 01 ） ; the levels of carcinoembryonic antigen （CEA） , alpha-fetoprotein （AFP） and gly- coprotein antigen （ CA125, CA153 and CA19-9 ） had abnormal change, and the elevation of CEA and CA125 were the most common. Conclusion Age 〉40 years, and the elevention of ESR, AST, CK and LDH in serum are the clinically relevant factors of DM with maliznancv.
出处
《中国肿瘤临床与康复》
2013年第9期938-940,共3页
Chinese Journal of Clinical Oncology and Rehabilitation
关键词
皮肌炎
肿瘤
流行病学
Dermatomyositis
Neoplasms
Epidemiological
