短效促性腺激素释放激素激动剂长方案的降调节模式与临床处理要点被引量：1

The down-regulation mode of short-acting GnRH agonist long protocol and clinical management

下载PDF

导出

摘要短效促性腺激素释放激素激动剂（GnRH—a）长方案仍然是目前体外受精一胚胎移植（IVF—ET）助孕治疗中的“金标准”方案。自1984年GnRH—a应用于IVF领域后，已有大量研究证实了其有效性。与单纯促性腺激素（Gn）促排卵比较，GnRH—a长方案能有效抑制早发内源性黄体生成素（LH）峰，减少取消周期，改善卵泡同步化，增加获卵数，提高卵母细胞和胚胎质量，改善子宫内膜接受性，提高妊娠率等优点，但伴随的缺点是增加Gn量，延长治疗时间，增加卵巢过度刺激综合征（OHSS）风险， The short-acting GnRH agonist long protocol is still a standard protocol in IVF. The down-regulation mode of short-acting GnRH agonist long protocol mainly includes two aspects：firstly,it requires at least 14 days of down-regulation of GnRH agonist for complete suppression of estradiol prior to ovarian stimulation; secondly, the antral follicle counts may change during down-regulation. Therefore, down-regulation of GnRH agonist long protocol needs at least 14 days; and appropriate prolongation of short-acting GnRH agonist down-regulation could improve the synchronization of follicular development.

作者叶虹

机构地区重庆市妇产科医院遗传与生殖研究所

出处《生殖医学杂志》 CAS 2013年第10期742-744,共3页 Journal of Reproductive Medicine

关键词短效促性腺激素释放激素激动剂降调节体外受精 Short-acting GnRH agonist Down-regulation IVF

分类号 R [医药卫生]

引文网络
相关文献

参考文献11

1I.emay A, Maheux R, Faure N, et al. Reversible hypogonadism induced by a luteinizing hormone-releasing hormone (LH-RH) agonist ( buserelin ) as a new therapeutic approach for endometriosis[J] Fertil Steril, 1984,41 : 863-871. 被引量：1
2Dada T, Salha O, Baillie HS, et al. A comparison of three gonadotrophin releasing hormone analogues in an in-vitro fertilization programme:a prospective randomized study[J]. Hum Reprod, 1999,14 : 288-293. 被引量：1
3Neveu S,Hedon B,Bringer J, et al. Ovarian stimulation by a combination of gonadotrophin-re|easing hormone agonist andgonadotropins for in vitro fertilizations[J]. Fertil Steril, 1987, 47:639-643. 被引量：1
4Kerin JF. The advantages of a gonadotrophin releasing hormone agonist (leuprolide acetate) in conjunction with gonadotrophins for controlled ovarian hyperstimulation in IVF and GIFT cycles [J]. Arch Gynecol Obstet,1989,246(Suppl) :$45 52. 被引量：1
5王玢,孙海翔,刘景瑜,胡娅莉,贺方方.适当延长GnRH-a降调节时间对卵泡发育同步性的影响[J].中华男科学杂志,2011,17(12):1087-1091. 被引量：15
6Ng EHY, Chan CCW, Tang OS, et al. Effect of pituitary downregulation on antral follicle count, ovarian volume and stromal blood flow measured by three-dimensional ultrasound with power Doppler prior to ovarian stimulation[J]. Hum Reprod, 2004,19 : 2811 2815. 被引量：1
7Jarvela IY, Sladkevieius P, Kelly S, et al. Effect of pituitary down-regulation on the ovary before in vitro fertilization as measured using three-dimensional power Doppler ultrasound [J]. Fertil Steril,2003,79 : 1129-1135. 被引量：1
8Hansen KR, Morris JL, Thyer AC, et al. Reproductive aging and variability in the ovarian antral follicle count:Application in the clinical setting[J]. Fertil Steril, 2003,80 : 577 583. 被引量：1
9Dada T, Salha O, Allgar V, et al. Utero ovarian blood flow characteristics of pituitary desensitization[J]. Hum Reprod, 2001,16 : 1663-1670. 被引量：1
10John L,Frattarelli MD. A prospective analysis of the changes in ovarian morphology during hormonal pituitary suppression before in vitro fertilization[J]. Fertil Steril, 2006,86 : 577-582. 被引量：1

二级参考文献9

1Ginther OJ, Kot K, Kulick IA, et al. Emergence and deviation of follicles during the development of follicular waves in cattJe. Theriogenology, 1997, 48( 1 ) : 75-87. 被引量：1
2Ginther OJ, Beg MA, Bergfelt DR, et al. Follicle selection in Monovular species. Biol Reprod, 2001,65 (3) : 638-647. 被引量：1
3Gougeon A, Lefevre B. Evolution of the diameters of the largest healthy and atretic follicles during the human menstrual cycle. Reprod Fertil, 1983,69 (5) : 497-502. 被引量：1
4Jarvela IY, Sladkevicius P, Kelly S, et al. Effect of pituitary down-regulation on the ovary before in vitro fertilization as measured using three-dimensional power Doppler ultrasound. Fertil Steril, 2003, 79(5) : 1129-1135. 被引量：1
5Fanchin R, Castelo Branco A, Kadoch IJ, et al. Premenstrual administration of gonadotropin-releasing hormone antagonist coordinates early antral follicle sizes and sets up the basis for an innovative concept of controlled ovarian hyperstimulation. Fertil Steril, 2004, 81 (6): 1554-1559. 被引量：1
6Fanchin R, Cunha-Filho iS, Schonaner LM, et al. Coordination of early antral follicles by luteal estradiol administration provides a basis for alternative controlled ovarian hyperstimulation regimens. Fertil Steril, 2003, 79(3) : 316-321. 被引量：1
7Hansen KR, Morris JL, Thyer AC, et al. Reproductive aging and variability in the ovarian antral follicle count: Application in the clinical setting. Fertil Steril, 2003, 80 (3) : 577-583. 被引量：1
8Frattarelli JL. A prospective analysis of the changes in ovarian morphology during hormonal pituitary suppression before in vitro fertilization. Fertil Steril, 2006, 86(3): 577-582. 被引量：1
9Seifer DB, MacLaughlin DT, Penzias AS. Gonadotropin-releasing hormone agonist-induced differences in granulosa cell cycle kinetics are associated with alterations in follicular fluid mullerian-inhibiting substance and androgen content. J Clin Endocrinol Metab, 1993, 76(8) : 711-714. 被引量：1