摘要
目的比较分析体外受精-胚胎移植(IVF-ET)周期应用促性腺激素释放激素(GnRH-ant)拮抗剂方案中用或未用口服避孕药(达英-35)预处理患者的临床特征和治疗结局。方法回顾性分析252个IVF-ET移植周期,分为3组,A组:116例,达英-35预处理GnRH-ant方案移植周期组;B组:46例,未用达英-35预处理GnRH-ant方案移植周期组;C组:90例,GnRH-a长方案移植周期组。比较各组患者的年龄、促性腺激素(Gn)使用天数和剂量、HCG日LH水平、取卵日内膜厚度、可用胚胎率、临床妊娠率等。结果 A组平均年龄(30.9±0.8)较B组(33.9±1.7)年轻,有显著性差异(P<0.05);A组Gn使用天数和用量比B组多,但无显著性差异(P>0.05);A组HCG日LH水平和取卵日内膜厚度均较B组显著减少(P<0.05);A组与B组的可用胚胎率无显著性差异(P>0.05);A组临床妊娠率(18.1%)较B组(37.0%)显著下降(P<0.05);B组临床妊娠率(37.0%)与C组(38.8%)相比较无显著性差异(P>0.05)。结论在IVF-ET治疗中应用口服避孕药预处理GnRH-ant方案,妊娠率显著下降,但未用口服避孕药预处理的GnRH-ant方案,能获得满意的临床结局。
Objective： To analyze the clinical features and outcome of patients who used or did not used oral contraceptive （Diane-35）pretreatment before gonadotropin releasing hormone antagonist （GnRH-ant） protocol during in vitro fertilization-embryo transfer（IVF-ET）cycles. Methods： All the IVF-ET cycles were divided to three groups. The patients in group A（n= 116）used oral contraceptive before GnRH-ant treatment. The patients in group B（n= 46）did not used oral contraceptive before GnRH-ant treatment. The patients in group C（n= 90）were applied with GnRH agonist（GnRH-a）long protocol cycle. Patient＇s age, dose and duration of gonadotropin treatment, serum LH levels on HCG day, endometrial thickness,clinical pregnancy rate etc. were compared among the three groups. Results： The patients＇ age in group A were significantly younger than group B（30.9±0.8 vs. 33.9± 1.7） （P〈0.05）. The dose and duration of gonadotropins（Gn）used in group A were higher than those in group B（P〉0.05）. The serum LH and the endometrial thickness in group A were significantly lower than those in group B（P〈0.05）. There were no significant differences in good quality embryos rates among the three groups. The clinical pregnancy rate in group A significantly decreased （18.0% vs. 37.0%）（P〈0.05）. There was no significant difference in clinical group B and group C（37.0% vs. 38.8%）. However the dose and duration significantly less than those in group C. compared with group B pregnancy rates between of Gn in Group B were Conclusions. Usage of oral contraceptive before GnRH-ant protocol significantly decreases pregnancy rate. However,GnRH-ant protocol without oral contraceptive pretreatment can get a comparable clinical outcome with GnRH-a long protocol.
出处
《生殖医学杂志》
CAS
2014年第4期296-300,共5页
Journal of Reproductive Medicine
