摘要
目的探讨儿童神经纤维瘤病Ⅰ型患者脑部病变MRI表现特点。方法回顾性分析8例临床确诊的儿童NFⅠ患者脑部MRI资料。8例均行常规MRI平扫,其中3例行增强扫描,1例行双侧基底节病变波谱采集,分析病变好发部位、数目、信号特点、强化形式及波谱。结果 8例病变均为多发,主要累及小脑(7例),累及基底节区8例,脑干受累7例,4例累及丘脑,1例视交叉增粗,形态多为斑片状,2例合并圆点状病灶,呈等或稍长T1信号、稍长T2信号;3例增强扫描病灶无明显强化。1例双侧基底节区病灶波谱显示胆碱/肌酸(Cho/Cr)分别为0.86与1.24。结论儿童神经纤维瘤病Ⅰ型患者颅脑病变具有特征性MRI表现,常多发,同时累及小脑、脑干、基底节区,部分累及丘脑,T2WI上表现为高信号,无强化。MRI可全面显示颅脑多发病变,为临床诊断及随访提供重要的依据。
Objective To illustrate MR characteristic of brain lesions in children with neurofibromatosis type Ⅰ （ NFⅠ ）. Methods MR images of 8 pediatric NF Ⅰ were reviewed. Contrast material was administered in 3 cases. 1 case performed Magnetic Resonance Spectroscopy. The MR images were analyzed with specific reference to the following： lesion numbers, location, morphology, signal characteristics , and presence or absence of contrast enhancement. Choline/Crea- tine （Cho/Cr）was calculated. Results Multiple hyperintense lesions on T2WI were found in the 8 patients. 7of lesions located in cerebellums,8 in the globus pallidus,7 in brainstems, 4 in halamus , 1 in chiasma. The lesions showed no con- trast enhancement. Cho/Cr of the bilateral globus pallidus was 0.86 and 1.24 in 1 case. Conclusion Brain MRI in chil- dren with NF I is characterized by muhiple lesions of prolonged T2 relaxation involving the brainstem, cerebellum, and globus pallidus, with no contrast enhancement. MRI can play important role in the diagnosis and follow up.
出处
《临床放射学杂志》
CSCD
北大核心
2013年第10期1479-1483,共5页
Journal of Clinical Radiology
关键词
颅脑
神经纤维瘤病I型
磁共振成像
Brain Neurofibromatosis type Ⅰ Magnetic resonance imaging
