摘要
药物诱导性自身免疫性疾病是长期用药引发的一种不良反应,表现为免疫系统对自身抗原进行反应的病理学过程,并最终会因机体丧失对自身抗原的免疫耐受而产生自身抗体。本文从药物性自身免疫性疾病的定义、动物模型、发生机制等方面对药物诱导性自身免疫性疾病进行综述,以进一步认识药物诱导性自身免疫反应,并且通过探讨药物诱导性自身免疫性疾病的发生机制,为药物性自身免疫毒性的评价以及预测提供帮助。
Drug-induced autoimmune disease is an adverse reaction caused by long-term medication. Per- formance of the pathological processes is the reaction of immune system to its own antigens. Eventually, the body losses the immune tolerance to auto-antigens and produces auto-antibodies. Here, the definition of drug-induced autoimmune disease, the animal models, the mechanism of drug-induced autoimmune disease were reviewed to fur- ther understand the drug-induced autoimmune response, helping us to improve the evaluation of drug-induced auto- immune reactions in preclinical toxicity study in the future.
出处
《中国新药杂志》
CAS
CSCD
北大核心
2013年第19期2244-2249,共6页
Chinese Journal of New Drugs
基金
国家"重大新药创制"科技重大专项药物安全评价技术平台(2012ZX09302001)
关键词
药物不良反应
自身免疫
毒理
D-青霉胺
安全评价
adverse drug reaction
autoimmunity
toxicity
D-penicillamine
safety evaluation
