摘要
目的探讨抑郁症情绪加工异常的脑功能特点。方法对24例青年首发抑郁患者及对照组进行HAMD量表评定，采用DTI对脑白质FA值测量，并进行情绪图片刺激的fMRI扫描，得出相关指标及影像学结果进行统计分析。结果抑郁组相比对照组的FA值差异有统计学意义的部位有：左右额叶（左额叶抑郁组0．324±0．090，对照组0．467±0．072，P〈0．01）、胼胝体膝（抑郁组0．614±0．146，对照组0．734±0．063，P〈0．01）、扣带回前部（抑郁组0．222±0．035，对照组0．343±0．021，P〈0．01）；抑郁组额叶FA值与病程呈负相关（r=-0．555，P〈0．01）。情绪刺激图片的脑激活区包括额、顶叶皮层一皮层下网状系统、边缘系统及下丘脑，并且两组受试识别情绪图片组间差异有统计学意义。结论抑郁患者存在情绪加工异常，额叶白质纤维束破环和灰质异常可能是其病理基础。
Objective To investigate the characteristics of the depression during emotional processing. Methods 24 participants with first episode of depression and healthy controls were assessed with HAMD scale, using DTI to dectect values of white matter FA, and using fMRI with pictures of emotional stimuli ; thus results re- lated with imagings were produced. The results were statistically analyzed. Results The brain areas indicating FA values deference with statistial significance in depression patients compared with the control ones included：left and right frontal lobe （ left frontal lobe depression group 0.324 ± 0. 090, control group 0. 467 ± 0. 072, P 〈 0. 01 ）, cor- pus callosum knee （ depression group 0.614 ± 0. 146, control group 0. 734 ± 0. 063, P 〈 0. 01 ）, anterior cingulate gyrus （ depression group 0. 222 ±0.035 ,control group 0. 343 ±0. 021, P〈0.01 ） ;the fronal FA values in depres- sion grop were negatively correlated with the duration of bilateral frontal white matter （ r = - 0. 555, P 〈 0.01 ）. The activation of emotional brain regions stimulated by pictures includes frontal cortex-subcortical reticular system, and the hypothalamus and limbic system . There was a significant difference between two groups. Conclusion - There may be abnormal emotional processing dystunction in patients with depression. It may be the pathological ba- sis to have frontal white matter fiber tracts broken.
出处
《中华行为医学与脑科学杂志》
CAS
CSCD
北大核心
2013年第9期807-809,共3页
Chinese Journal of Behavioral Medicine and Brain Science
基金
国家自然科学基金（81271655/1810）
广东省自然科学基金（S2011040004584）
关键词
抑郁症
情绪加工
弥散张量成像
功能磁共振
Depression
Emtional processing
Dffusion tensor imaging
Functional magnetic resonance
