摘要
目的探讨颈动脉内膜中层厚度(CIMT)与类风湿性关节炎相关的临床及实验室指标的相关性,为类风湿性关节炎的防治提供依据。方法检测80例类风湿性关节炎患者及50例健康者的CIMT,并收集病例组临床及实验室相关指标,采用Pearson相关分析、多重线性回归分析等进行分析。结果病例组CIMT明显高于对照组(P<0.05);CIMT与年龄、年龄、ACPA、ESR、总胆固醇、NT-proBNP、LDL、SCORE等指标均呈正相关关系,年龄及NT-proBNP对CIMT的影响最大;CIMT<0.8 mm的患者,年龄小、SCORE值低、血清总胆固醇、NT-proBNP、CRP更低、病程更短、变脆弱的关节数越小(P<0.05)。结论类风湿性关节炎患者的CIMT比对照组明显升高,并与类风湿性关节炎的免疫学和炎症相关指标有关;年龄升高、关节外症状、NT-proBNP浓度升高等均可能增加动脉粥样硬化的危险性。
Objective To investigate the correlation of carotid artery intima-media thickness （CIMT） and rheumatoid arthritis-related clinical and laboratory indicators, providing the basis for the prevention and treatment of rheumatoid arthritis. Methods Eighty RA patients and 50 healthy subjects were selected to test the CIMT and clinical and laboratory related indicators. Pearson correlation analysis and multiple linear regression analysis were used to analyze the correlation. Results CIMT of the patients was significantly higher than that of the control group （P〈0.05）; A positive correlation between CIMT and age,ACPA,ESR,total cholesterol,NT-proBNP,LDL, SCORE was founded; Patients with CIMT 〈0.8mm were more younger, SCORE value, serum total cholesterol,NT-proBNP,CRP was lower, duration was shorter, the number of joints weakened was smaller （P〈0.05）. Conclusion CIMT of patients with rheumatoid arthritis was significantly higher than that of the control group, and correlated with rheumatoid arthritis immunology and inflammation-related indicators;ages,articular symptoms, NT-proBNP concentration may increase the risk of atherosclerosis.
出处
《中国现代医生》
2013年第29期31-32,35,共3页
China Modern Doctor
