摘要
目的探讨影响原发性肝癌切除术后生存时间的因素，为预测预后提供依据。方法回顾性分析接受手术切除的172例原发性肝癌患者的临床资料，采用Kaplain．Meier法计算生存率，用Log．rank检验进行单因素分析，Cox比例风险模型进行多因素分析，最终筛选出对原发性肝癌切除预后有影响的临床病理因素。结果患者的中位生存期为18个月，单因素分析显示：肝功能Child—Pugh分级、肝硬化、肿瘤大小、乙肝病史、甲胎蛋白（AFP）、门静脉癌栓是影响生存率的重要因素（P〈0．05），而多因素分析则提示肝功能Child—Pugh分级、肿瘤大小、AFP、门静脉癌栓是影响肝癌术后预后的重要独立因素（P〈0．05）。结论肝功能Child—Pugh分级、肿瘤大小、AFP、门静脉癌栓是肝癌患者术后预后的独立影响因素。
Objective To explore the factors related to the prognosis and survival duration of primary liver cancer patients after hepatectomy. Methods The data of primary liver cancer patients ＇who were treated by surgical resection were analyzed retrospectively. Kaplain-Meier method was used to evaluate survival rates. Log-rank test and Cox regression analysis were used to screen out related clinical phathology factors. Results The median survival time was eighteen months. Univarivate analysis showed that liver function Child-Pugh classification, cirrhosis, tumor size, HBV infection, AFP, portal vein tumor thrombus significantly correlated with survival rates （P 〈 0.05）. Multivariate analysis showed that liver function Child-Pugh classification, tumor size, AFP and portal vein tumor thrombus were the independent prognostic factors of primary liver cancer （P 〈 0.05）. Conclusion Many factors are related to the prognosis of primary liver cancer after operation. Liver function Child-Pugh classification, tumor size, AFP and portal vein tumor thrombus affect prognostic independently.
出处
《肿瘤研究与临床》
CAS
2013年第9期588-590,共3页
Cancer Research and Clinic
基金
川北医学院苗圃基金（MP-09A-40）
关键词
肝肿瘤
肝切除术
预后因素
生存率
Liver neoplasms
Hepatectomy
Prognosis factor
Survival rate
