摘要
H5N1亚型禽流感病毒是目前发现的禽流感病毒中感染性最强、致死率最高、流行最广的一类病毒,该病毒已在世界上多个国家发生流行,给禽类养殖业带来了巨大的经济损失。当前针对该病尚无高效特异的治疗方法,进行疫苗的接种是目前最为有效的预防措施和关键环节。因此,研制安全、高效、廉价的新型疫苗成为当前禽流感防制工作的热点之一,且取得了大量的研究成果。作者从禽流感病毒灭活疫苗、减毒活疫苗、基因工程疫苗和RNAi技术应用等方面对H5N1亚型禽流感病毒疫苗的研究现状作一综述,归纳出该领域中存在的问题和不足,并对禽流感疫苗的应用前景作一展望,以期为深入进行禽流感的防制研究提供参考。
The H5N1 subtype avian influenza virus （AIV） had been known as a pathogen with specialties of the strongest infection, the highest mortality and the widest epidemic. H5N1 subtype AIV was endemic in many countries around the world and had caused considerable economic losses to the poultry industry. However, owing to no effective treatment measures, vac- cine inoculation had become the most-effective prevention measure and the key loop. Therefore,the development of the safe, high-efficiency and low-cost vaccine was one of the current hotspots for the control of avian influenza. Based on the large num- bers of research achievements of avian influenza vaccine, we comprehensively described the research status of avian influenza vaccine from the following aspects,the virus inactivated vaccine, attenuated live vaccine, genetic engineering vaccine and other technology application etc. Moreover, we summarized the difficulties and drawbacks of studies and gave the future prospects of vaccine application with the purpose of providing a comprehensive background and reference for the control of avian influenza.
出处
《中国畜牧兽医》
CAS
北大核心
2013年第9期208-213,共6页
China Animal Husbandry & Veterinary Medicine
基金
河南省科技厅科技攻关项目(112102110103)
河南省教育厅科技攻关项目(2010B180010)
河南省高等学校青年骨干教师资助项目(2012GGJS-080)
