摘要
目的比较不同物种和品系的哺乳类实验动物对H5N1禽流感病毒(AIV)致病的敏感性。方法对不同动物经鼻腔接毒,然后通过体温、体重、临床症状、病理变化、病毒分离和抗体测定进行比较分析。结果在实验的4个不同物种共7个品系的哺乳动物中,小鼠对AIV较豚鼠、沙鼠和大鼠敏感。结论ICR和NIH小鼠适宜用来制作AIV感染的动物模型。
Objective To compare the pathogenicity of avian influenza virus to different mammals. Methods\ Four different species of mammal were selected, receiving the AIV through nasal cavity; then the changes of body temperature,body weight,clinical signs and pathology were observed, the virus from the experimental animals isolated and the antibody detected. Results Among mouse,rat,cavia cobaya and gerbil, mouse is the most sensitive animal model to AIV. Conclusion ICR and NIH mouse are suitable animal models for Avian influenza infection.
出处
《中国实验动物学报》
CAS
CSCD
2004年第4期212-214,共3页
Acta Laboratorium Animalis Scientia Sinica
