摘要
目的观察益气健脾汤联合高效抗逆转录病毒疗法(HAART)对艾滋病病毒(HIV)感染者或艾滋病(AIDS)患者临床疗效指标的影响。方法 86例患者随机分为治疗组和对照组各43例,治疗组采用益气健脾汤药联合HAART治疗,对照组单纯HAART治疗。观察两组患者治疗前及治疗后6、12个月的CD4+计数、症状体征积分、Karnofsky积分及丙氨酸氨基转移酶(ALT)水平,治疗12个月后判断终点事件发生率。结果治疗组5例(11.63%)发生终点事件,对照组为6例(13.95%),两组比较差异无统计学意义(P>0.05)。两组治疗后6个月及12个月,症状体征积分降低、Karnofsky积分升高(P<0.05);两组症状体征积分、Karnofsky积分治疗后6个月比较差异有统计学意义(P<0.05),治疗组优于对照组。两组治疗后6个月和12个月CD4+计数均较疗前升高(P<0.05);两组治疗后6个月和12个月同时间比较差异均无统计学意义(P>0.05)。治疗后6个月和12个月治疗组ALT降低、对照组ALT升高,与治疗前比较差异有统计学意义(P<0.05);两组治疗后12个月差异有统计学意义(P<0.01)。结论益气健脾汤联合HAART治疗HIV感染者和AIDS患者具有改善症状体征、提高生存质量的作用,在减轻肝损伤方面具有优势。
Objective To observe the therapeutic effect of qi-boosting spleen-fortifying therapy combined with highly active antiretroviral therapy （HAART） on human immunodeficiency virus infection/acquired immunodeficiency syndrome （HIV/ AIDS）. Methods Totally 86 cases of HIV/AIDS were randomized into the treatment group and control group, with 43 cases in each. The treatment group was given qi-boosting spleen fortifying formulas combined with HAART. The control group was given HAART. Observed indicators including CD4 ~ T cell count, symptom and sign integral, Karnofsky performance scale （KPS） and liver function before, 6 months and 12 months after treatment. The therapeutic effect was judged after 12-month treatment. Results There were 5 cases （11.63~） and 6 cases （13.95~） of endpoint events occurred in the treatment group and control group respectively, with no significant difference between groups （P^0.05）. The symptom and sign scores were significantly decreased but the KPS scores were significantly increased in both groups after 6-month and 12-month treatment （P〈0. 05）. There were significant differences between groups in the symptom and sign scares and KPS scores after 6-month treatment （P〈0.05）, but there was no significant difference between groups after 12-month treatment （P〈0.05）. The CD4＋ T cell count was significantly increased in both groups after 6-month and 12-month treatment （P〈 0.05）, but with no significant difference between groups （P〈0.05）. The level of Alanine aminotransferase （ALT） was significantly decreased in the treatment group but significantly increased in the control group after 6-month and 12-month treatment （P〈0.05）. There was no significant difference between groups in ALT after 6-month treatment （P〉0. 05）, but with a significant difference between groups after 12-month treatment （P〈0.01）. Conclusion The combo therapy of qi-boosting spleen-fortifying therapy and HAART can relieve symptoms and signs, improve quality
出处
《中医杂志》
CSCD
北大核心
2013年第19期1657-1659,共3页
Journal of Traditional Chinese Medicine
基金
北京市中医药科技项目(JJ2008-016)
关键词
益气健脾汤
艾滋病
高效联合抗反转录病毒治疗
终点事件
qi-boosting spleen-fortifying therapy
acquired immunodeficiency syndrome~ highly active antiretroviral therapy
endpoint events
