摘要
内毒素是革兰阴性细菌细胞壁中的脂多糖（LPS）组分.只有当细菌死亡溶解或用人工方法破坏菌细胞后才释放出来.血中细菌或病灶内细菌释放出大量内毒素至血液,或输入大量内毒素污染的液体而引起的一种病理生理表现称作内毒素血症.内毒素血症可以导致多种肝脏疾病的产生,其发生机制比较复杂,其中Toll样受体-4（TLR4）、CD14受体及Kupffer细胞在内毒素性肝损害的发生发展中起着重要作用.近年来,对于内毒素血症和肝脏疾病的临床和实验研究有了较大进展.
Endotoxin is the lipopolysaccharide （LPS）component of the Gram-negative bacterial cell wall.It can be released when the bacteria are dissolved after death or damaged by artificialmeans.Endotoxemia is known as a pathophysiological manifestation that is caused by the release a large amounts of endotoxin form the bacterial to blood.Transfusion of a large amount of liquid polluted by endotoxin can also cause endotoxemia.Endotoxemia can lead to a variety of liver diseases with unknownmechanism,Toll-like receptor-4 （TLR4）,CD14 receptor and Kupffer cells play important roles in the development of endotoxin-induced liver injury.
出处
《国际免疫学杂志》
CAS
2013年第5期359-362,共4页
International Journal of Immunology
基金
天津市教委基金（20050320）
天津市科委基金（11JCZDJC19900）
