摘要
脑衰反应调节蛋白2(CRMP2)在神经元发育过程中发挥着重要作用。CRMP2具有多种翻译后修饰方式和生物学功能,其中磷酸化修饰与神经系统疾病最相关,但其具体机制及生物学作用尚不清楚,有待进一步研究。CRMP2的研究为防治相关神经系统疾病提供了新的方向。
Collapsin response mediator protein 2 (CRMP2) plays a crucial role in neuronal development. It owns lots of post-translational modifications, of which phosphorylation modification is related to diseases closely. CRMP2 also has many biological functions. There is a close relationship between CRMP2 and neurologic disorders, but the mechanism is required to be elucidated. The researche in CRMP2 provides some new strategies to prevent and cure the related diseases.
出处
《基础医学与临床》
CSCD
北大核心
2013年第10期1332-1336,共5页
Basic and Clinical Medicine
基金
国家自然科学基金(31200895)
首都医科大学基础与临床合作课题(12JL44
12JL-L09)