摘要
对儿童过敏性紫癜临床表现特点及流行病学的深入研究揭示遗传因素与本病发病及病理过程密切相关。近年来分子生物学的研究显示，与IgA1异常糖基化密切相关的C1GALT1基因及几基因、血管舒缩和内皮功能调节基因、血管紧张素转化酶基因、血管紧张素原基因、MEFV基因等与儿童过敏性紫癜密切相关。该文就近年来与过敏性紫癜发病相关的遗传学机制研究进展作一综述。
The research on the clinical characteristic and epidemiology in Henoch-Schonlein purpura of children indicates that genetic factors are closely connected with the disease and pathological process. In recent years, molecular biology studies show that C1 GALT1 gene, IL gene, vasomotor and endothelial function regula- tion genes, angiotensin-converting enzyme gene, angiotensinogen gene, MEFV gene and so on, which have aber- rant IgA1 glycosylation, are closely related with pathogenesis of Henoch-Schonlein purpura in children. The paper reviews the progress of genetic mechanism associated with Henoch-Schonlein purpura in recent years.
出处
《国际儿科学杂志》
2013年第5期497-500,共4页
International Journal of Pediatrics
关键词
过敏性紫癜
儿童
异常糖基化IgA1
基因
Henoch-Schonlein purpura
Children
Aberrant glycosylation IgA1
Gene
