摘要
在三氯氧磷存在下,以甲氧基苯甲酸、氨基硫脲为原料,通过直接加热和微波加热两种方式,合成3个2-氨基-5-取代基-1,3,4噻二唑.通过优化工艺条件,得到传统热反应最佳条件,即反应温度为75℃,反应时间为4h,三氯氧磷与酸的摩尔比为4∶1,所得产物经熔点测试、红外光谱和核磁共振氢谱进行了确认.
In the presence of phosphorus oxychloride, three kinds of 2-amino-5-methoxylphenyl-1,3,4-thiadiazoles have been synthesized from methoxybenzoic acid and thiosemicarbazide under direct heating and microwave-assisted heating conditions. Through optimizing the reaction conditions, we concluded the ideal conditions for direct heating： the tempera- ture is 75℃, the reaction time is 4 h, and the mole ratio of phosphorus oxychloride and acid is 4 ~ 1. The obtained prod- ucts have been characterized by melting point, FT-IR and 1H NMR.
出处
《华侨大学学报（自然科学版）》
CAS
北大核心
2013年第5期539-541,共3页
Journal of Huaqiao University(Natural Science)
基金
江苏省高校自然科学研究重大基金资助项目(10KJA170003)
江苏省高校科研成果产业化推进研究基金资助项目(JHB2012-60)
江苏省连云港市科技攻关项目(CG1105)
