摘要
目的 调查男男性接触（MSM） HIV感染者早期接受艾滋病抗病毒治疗意愿及其影响因素.方法 2012年6-8月,采用方便抽样方法,从杭州市和宁波市艾滋病综合防治数据库中选取能够配合调查的MSM感染者作为调查对象.共有280例未开始抗病毒治疗的MSM HIV感染者接受了调查.采用自行设计的问卷,调查了其人口学特征、艾滋病知识知晓情况、性行为信息、安全套使用情况、目前身体状况、对于早期抗病毒治疗的认知情况及接受意愿等相关信息.剔除其中60例CD4＋T细胞水平不符合纳入标准的感染者后,共有220例纳入分析.采用x2检验比较不同特征调查对象早期抗病毒治疗可接受性的差异,应用非条件logistic回归分析研究早期抗病毒治疗可接受性的影响因素.结果 HIV感染者早期抗病毒治疗的接受率为62.7％ （138/220）.认为早期抗病毒治疗可以延缓发病、可以预防性伴感染、不担心周围人怀疑自己有病和性伴不知晓感染状况者具有较高的可接受意愿,可接受率分别为68.8％（130/189）、68.7％ （103/150）、78.4％（69/88）、72.5％（74/102）,与之相对应者的可接受率分别为24.1％（7/29）、50.0％（30/60）、52.7％（68/129）、45.8％（58/107）,差异均有统计学意义（x2值分别为21.46、6.43、14.84、7.55,P值均＜0.05）.logistic回归分析结果显示,认为早期抗病毒治疗可以延缓发病（OR=11.50,95％CI：3.29～40.22）和认为可以预防性伴感染（OR =3.72,95％ CI：1.53～9.03）的感染者更倾向于接受早期抗病毒治疗,而担心周围人怀疑自己有病（OR =0.19,95％CI：0.08 ～ 0.48）和性伴知晓其感染状况（OR =0.31,95％ CI：0.13～0.70）的感染者更倾向于不接受早期抗病毒治疗.结论 MSM HIV感染者早期抗病毒治疗可接受性较高,对于早期抗病毒治疗的认识、隐私泄露的顾虑是促进其接受治疗的主要影响因素.
Objective To assess the acceptability and influence factors of early antiretroviral therapy （ART） among HIV-positive men who have sex with men （MSM）.Methods From June to August 2012,through convenience sampling,HIV-positive MSM who were willing to cooperate with the survey were selected from the Hangzhou and Ningbo AIDS prevention and control database.A total of 280 HIV-positive MSM who did not receive ART participated in the study.Using self-designed questionnaire,general demographic information,awareness of AIDS knowledge,sexual behavior,use of condom,current physical condition,awareness and attitude towards early ART were investigated.Excluding 60 HIV-infected MSM whose CD4 ＋ T count didn＇ t meet the inclusion criteria,a total of 220 subjects were included in the analysis.Chi-square was used to compare the difference of early ART acceptance among subjects with different characteristics.Non-conditional logistic regression was used to analyze the influence factors of the acceptability of early ART.Results The acceptance rate of early ART among HIV-infected MSM was 62.7％ （138/220）.Delaying the disease development,preventing partners from infection,not worrying others to suspect them of having HIV,and partners unknowing the HIV-infected status were the factors which had a relatively higher acceptance rate of early ART.Correspondingly,the acceptance rate was 68.8％ （130/189）,68.7％ （103/150）,78.4％ （69/88） and 72.5％ （74/102） respectively and the acceptance rate among subjects with opposite opinions or characteristics was 24.1％ （7/29）,50.0％ （30/60）,52.7％ （68/129） and 45.8％ （58/107） respectively （chi-square values were 21.46,6.43,14.84 7.55,all P values ＜ 0.05）.Logistic regression analysis showed that delaying the disease development （OR =11.50,95％ CI：3.29-40.22） and preventing partners from infection （OR =3.72,95％ CI：1.53-9.03） were inclined to the acceptance of early ATR.While concerning others＇ suspection of them having HIV （O
出处
《中华预防医学杂志》
CAS
CSCD
北大核心
2013年第9期843-847,共5页
Chinese Journal of Preventive Medicine
