摘要
目的分析糖化清蛋白(GA)/糖化血红蛋白(HbA1c)比值以及谷氨酰转肽酶(GGT)和凝血酶原时间国际标准化比值(PT-INR)等指标在肝硬化等5种肝脏疾病中的意义。方法选取伴随或不伴随2型糖尿病(2DM)的肝硬化和肝癌等患者,测定并分析其GA/HbA1c比值以及GGT和PT-INR的改变。使用受试者工作特征曲线对GA/HbA1c比值应用于上述疾病的诊断价值进行评价。结果不伴DM的肝硬化和肝癌患者的GA/HbA1c比值较对照组明显升高,差异有统计学意义(P<0.05),但伴随2DM的肝硬化和肝癌患者GA/HbA1c比值与对照组比较差异无统计学意义(P>0.05)。GA/HbA1c比值对不伴DM的肝硬化患者的诊断界值为3.55,GA/HbA1c比值对不伴DM的肝癌患者的诊断界值为3.41,GA/HbA1c比值与GGT和PT-INR对上述5种肝脏疾病的诊断价值无相关性。结论关注GA/HbA1c的比值的变化对不伴2DM的肝硬化和肝癌患者的诊断有一定价值。
Objective To determine and analysis the ratio of glycated albumin（GA）and glycated hemoglobin（HbA1c）,prothrombin time international standardization ratio（PT-INR）and glutamyl transpeptidase（GGT）in 5kinds of hepatic diseases.Methods The GA,HbA1c,PT-INR and GGT were determined in hepatic disease（cirrhosis,liver cancer,etc）patients with or without type 2diabetes mellitus（2DM）.ROC curve was used to evaluate the diagnose values of these indexes.Results The ratio of GA/HbA1cin cirrhosis and liver cancer patients without 2DM were significantly higher than that in control group（P〈0.05）.There was no significant difference between cirrhosis and liver cancer patients with 2DM（P〈0.05）.The diagnosis point of GA/ HbA1cin cirrhosis and liver cancer patients without 2DM were 3.55and 3.41respectively.There was no relativity between GA/ HbA1cand GGT,PT-INR respectively.Conclusion The ratio of GA/HbA1cwas valuable to the diagnosis of cirrhosis and liver cancer patients without 2DM.
出处
《国际检验医学杂志》
CAS
2013年第18期2400-2401,共2页
International Journal of Laboratory Medicine
