摘要
目的回顾性分析金黄色葡萄球菌和耐甲氧西林金黄色葡萄球菌（MRSA）的耐药性变迁情况，为预防控制措施的制定提供依据。方法对2009-2012年临床分离的576株金黄色葡萄球菌进行分析，细菌鉴定和药敏试验采用VITEK2Compact全自动细菌培养鉴定仪。结果2009-2012年MRSA的分离率为59．5％，但每年的分离率呈逐年递减趋势。MRSA对万古霉素、利奈唑胺、奎奴普丁／达福普汀、替考拉宁、呋喃妥因的抗菌活性较好（耐药率〈2．4％）；对替加环素的耐药率和敏感率均为0．0％，中介率为100．0％；对庆大霉素、环丙沙星、莫西沙星、克林霉素、四环素和红霉素的耐药性呈逐年递减趋势。2010—2012年对复方磺胺甲嗯唑耐药性明显降低，由2010年的65．3％降至2011年和2012年的28．2％和4．7％（P〈0．05）。结论MRSA的分离和耐药性逐年递减，应继续加强抗菌药物管理，合理科学使用抗菌药物，降低多重耐药细菌的发生率和耐药性。
Objective To retrospectively analyze the drug resistance evolution of Staphylococcus anreus and MRSA, to provide the basis for prevention and control measures. Methods 576 strains of clinical isolated Staphylo- coccus aureus from 2009 to 2012 were analyzed. The bacteria identification and drug sensitivity test were detected by VITEK 2 Compact automatic bacteria identification instrument. Results The separation rate of MRSA from 2009 to 2012 was 59.5% ,but the separation rate was gradually decreased per year. The antibacterial activity of MRSA was better to vancomycin, linezolid, quinupristin/Dalfopristin, teicoplanin, nitrofurantoin （ resistance rate 〈 2.4% ）. The resistance rate and sensitive rate of MRSA to tigeeyeline was 0.0% ,intermediary rate was 100.0%. The resistance of MRSA to gentamicin, ciprofloxacin, moxifloxacin, clindamycin, tetracycline and erythromycin was gradually decreased. From 2010 to 2012 ,The resistance of MRSA to cotrimoxazole decreased significantly,from 65.3% in 2010 to 28.2% in 2011 and 4.7% in 2012 （P 〈 0.05 ）. Conclusion Separation of MRSA and drug resistance is reduced year by year, we should continue to strengthen the administration of antimicrobial agents, scientific and reasonable application of antibacterial drugs, reduce the incidence of multiresistant bacteria and drug resistance.
出处
《中国基层医药》
CAS
2013年第22期3361-3363,共3页
Chinese Journal of Primary Medicine and Pharmacy
基金
内蒙古自治区卫生厅医疗卫生科研计划项目（2010102）
关键词
金黄色葡萄球菌
耐药性变迁
抗菌药物
Staphylococcus aureus
Drug resistance evolution
Antibacterial drugs
