摘要
为了解滇池微囊藻毒素对小鼠肝脏的损伤作用,提取滇池水华水样中微囊藻毒素对小鼠进行连续灌胃试验,之后取肝组织石蜡包埋、HE染色,观察小鼠肝脏组织显微结构.结果显示:小鼠肝脏充血、肿胀;微囊藻毒素使小鼠肝脏组织的显微结构出现异常变化,肝细胞索结构破坏,肝血窦明显扩张,部分肝细胞胞质溶解、核消失,病灶内有大量炎症细胞浸润.表明微囊藻毒素具有肝毒性,可破坏肝小叶的完整性,抑制肝脏的合成与解毒功能.
To study whether Microcystin in Dianehi Lake injury liver of mice, mice were intragastrically administered by Microcystin extracted from Dianchi Lake Water-Blooms samples. Paraffin sections of liver were stained by HE staining and observed under micro- scope. The result displayed that livers of mice were congested and swelled after intragastrically administered Microcystin; mictrostruc- ture of liver became abnormal; hepatic cell cords were destroyed; hepatic sinusoid expanded obviously; cytoplasm of some liver cells dissolved; nuclear disappeared, and severe inflammatory cells infiltration were found in lesion area. In conclusion, Microcystin has hepatotoxic effects that destroy hepatic lobule structure to inhibit synthesis and detoxify of liver
出处
《昆明学院学报》
2013年第3期45-47,共3页
Journal of Kunming University
基金
昆明学院科学研究资助项目(XJL12023)
