摘要
基膜蛋白聚糖是一类主要分布于膜性结构的大分子硫酸乙酰肝素蛋白聚糖,可结合并释放多种生长因子,参与多种细胞的黏附、增殖和分化等过程。本文就基膜蛋白聚糖参与软骨和骨的发育、对骨修复生长因子的作用、参与细胞的黏附和迁移以及骨修复中细胞的分化和增殖过程的研究进展作一综述。
Perlecan, an important basement-membrane-component, is a large heparan sulfate proteoglycan involved in growth factor sequestration and delivery, thereby enhancing cell adhesion, proliferation, and differentiation. This review aims to discuss the recent progress of perlecan on bone and cartilage development, as well as its function in cell growth, adhesion, and proliferation during bone remodeling.
出处
《国际口腔医学杂志》
CAS
2013年第5期691-694,共4页
International Journal of Stomatology
基金
国家自然科学基金资助项目(30900300)
