摘要
目的:分析组蛋白去乙酰化酶(1HDAC1)及沉默信息调节因子1(SIRT1)在喉鳞癌中的表达及意义。方法:采用免疫组化SP法检测46例喉鳞癌组织及其癌旁正常的喉黏膜组织中的HDAC1、SIRT1表达水平,并分析HDAC1、SIRT1的表达与患者性别、年龄、病理学分级、临床分期、临床分型、有无淋巴结转移、预后的关系。结果:癌组织中的HDAC1主要表达于胞核、SIRT1主要表达于胞浆;HDAC1、SIRT1在喉鳞癌中的表达率分别为79.09%及82.61%,在癌旁正常喉黏膜组织中的表达率分别为8.69%及8.69%;HDAC1、SIRT1的表达与患者性别、年龄、病理学分级、临床分期及临床分型无关,HDAC1与淋巴结的转移和预后有关(P<0.05),SIRT1与预后有关(P<0.05),与淋巴结转移相关性不明显。结论:HDAC1、SIRT1在喉鳞癌组织中高表达,HDAC1与淋巴结的转移和预后有关,SIRT1与预后有关。
Objective： To analyze histone deacetylase 1 （HDAC1）, and silent information regulator factor 1 （SIRT1） expression in laryngeal squamous cell carcinoma （LSCC） and its clinical significance. Methods： Expression of HDAC1, and SIRT1 in LSCC and adjacent normal laryngeal mucosa of 46 pa- tients was analyzed by using immunohistochemistry SP method, and the relationship of the expression with the disease situation was studied. Results： The expression rates of HDAC1 and SIRT1 in LSCC and adjacent tissues were 79.09%, 8.69%, and 82.61%, 8.69% respectively. In carcinoma, HDAC1, and SIRT1 were mainly expressed in the nucleus and cytoplasm of tumor cells. The expression of HDAC1, SIRT1 was independent of patient gender, age, pathological grade, clinical stage and patholog- ical classification, but related to prognosis and / or lymph node metastasis. Conclusion： HDAC1, and SIRT1 highly express in laryngeal squamous cell carcinoma, and its expression relates to the lymph node metastasis and/or prognosis.
出处
《贵阳医学院学报》
CAS
2013年第4期356-358,共3页
Journal of Guiyang Medical College
基金
贵州省科学技术基金资助:黔科合J字[2009]-2292
关键词
喉肿瘤
癌
鳞状细胞
组蛋白脱乙酰基酶类
沉默信息调节因子
免疫组织化学
laryngeal neoplasms
carcinoma, squamous cell
histone deacetylases
silent informa- tion regulator factor
immunohistochemistry
