摘要
血小板和内皮细胞之间相互作用的典型例子系血管损伤。近年来,随着对血小板功能研究的不断深入,发现血小板和内皮细胞亦参与了炎症、肿瘤和淋巴管发育。在上述情况下,循环中的血小板被激活并表达黏附分子和脱颗粒。黏附分子和颗粒内容物通过改变内皮细胞渗透性、黏附性、生存、增殖以及迁移能力,介导炎症、肿瘤和淋巴管发育。这些研究成果,使得血小板与内皮细胞之间的关系内涵更加广泛,意义更加深远。本文针对近年来血小板和内皮细胞在炎症、肿瘤以及淋巴管发育研究中的进展和前景予以综述。
Endothelial lesion is the most well known example for the interaction between platelets and endothelial cells,but the recent researches indicate that platelets and endothelial cells also participate in inflammation,tumor metastasis and lymphovascular development.Under these situations,the activated platelets express adhesive molecules and degranulate,and regulate the permeability,adhesion,survival,proliferation and metastasis of endothelial cells.All the achievements push the research on the interaction between platelets and endothelial cells to a new era,which would be more significant.In this review,the latest advances and prospect of the interaction between platelets and endothelial cells in inflammation,tumor and lymphovascular development are summarized.
出处
《中国实验血液学杂志》
CAS
CSCD
北大核心
2013年第4期1078-1082,共5页
Journal of Experimental Hematology
关键词
血小板
内皮细胞
炎症
肿瘤
淋巴管发育
platelet
endothelial cell
inflammation
tumor
lymphovascular development
