摘要
目的:研究CD44v6在胃癌胃镜标本和术后标本中的表达,并分析其与胃癌生物学行为的关系.方法:随机选取辽宁医学院附属第二医院普通外科2004-2009年收治的有详细病例资料的胃癌患者50例,应用免疫组织化学方法检测胃镜标本和术后标本胃组织中CD44v6的表达.结果:CD44v6在胃癌胃镜标本、术后标本和转移淋巴结中的表达率分别为60.00%、64.00%、80.77%,显著高于胃良性病变(P<0.01);CD44v6在肠型胃癌中的表达率显著高于弥漫型胃癌(75.86%vs47.62%,P<0.05).胃癌胃镜和术后标本中CD44v6的表达与胃癌浸润深度,TNM分期和淋巴结转移均有关(P<0.05).CD44v6在胃癌胃镜标本和术后标本中的总体表达率无显著性差异(P>0.05);相同临床病理参数,CD44v6在胃癌胃镜标本和术后标本中的表达率无显著性差异(P>0.05).结论:CD44v6可作为术前预测胃癌的发生、病期进展和转移潜能的辅助生物学指标之一.
AIM： To investigate the expression of CD44v6 in gastric cancer and analyze its relationship with tumor biological behavior. METHODS： Fifty patients with gastric carcinoma, who were treated at the Second Affili-ated Hospital of Liaoning Medical University between 2004 and 2009 and had detailed patho-logical data, were included in the study. The expression of CD44v6 in operative and gastro-scopic samples collected from these patients was detected by immunohistochemistry using the streptavidin-peroxidase method. RESULTS： The positive rates of CD44v6 expression in gastroscopic and operative samples and metastatic lymph node samples were 60.00%, 64.00% and 80.77%, respectively, significantlyhigher than that in benign gastric mucosa lesions （all P 0.01）. The positive rate of CD44v6 expression in intestinal-type gastric carcinoma tissue was significantly higher than that in diffuse-type gastric tissue （75.86% vs 47.62%, P 0.05）. The expression of CD44v6 was significantly correlated with the depth ofinvasion, TNM stage and lymph node metastasis in gastroscopic and operative samples （all P 0.05）. There was no significant difference in the positive rate of CD44v6 expression between gastroscopic and operative samples （P 0.05）. CONCLUSION： CD44v6 may be used as a new parameter for preoperative prediction of the development, progression and metastatic potential of gastric carcinoma.
出处
《世界华人消化杂志》
CAS
北大核心
2010年第6期610-615,共6页
World Chinese Journal of Digestology
