摘要
目的预防性保肝治疗对抗结核疗效的影响。方法收集我科接受住院治疗的322例单纯肺结核及伴有HBV携带患者的临床资料,分析肝损害出现的时间、年龄、损害程度与HBV感染的关系。结果无论是否携带HBV,接受预防性保肝治疗的肺结核患者肝损害的发生率明显低于未行保肝治疗组;>60岁的结核病人肝损害的发生率明显高于≤60岁;肺结核伴有HBV携带患者肝损害比率明显高于非HBV携带肺结核患者。结论高龄、HBV携带的肺结核患者是抗结核药物导致肝损害的高危人群,预防性保肝治疗能减少抗结核治疗中肝损害的发生,利于顺利完成化疗疗程。
Objective To explore the effect of prophylactic hepato-protected treatment on anti-tuberculosis chemotherapy. Meth- ods The clinical data of 322 patients with pulmonary tuberculosis complicated with HBV infection were collected to analyze the relation- ship of their age and hepatic lesion to HBV infection. Results （ 1 ） The incidence of hepatic lesion was obviously higher in patients who were older than 60 years old than those younger than 60 years old, no matter the patients were complicated with HBV infection or given prophylactic hepato-pmtected treatment. （2） Patients who had pulmonary tuberculosis combined with HBV infection had higher incidence of liver injury than patients with pulmonary tuberculosis only. （3） Patients who received prophylactic hepato-protected treatment had less liver injury, no matter they were complicated with HBV infection or not. Conclusion Elderly patients and pulmonary tuberculosis pa- tients complicated with HBV infection are more likely to subject liver injury. Prophylactic hepato-protected treatment can reduce the occur- rence of liver injury and complete chemotherapy smoothly.
出处
《临床肺科杂志》
2013年第10期1851-1853,共3页
Journal of Clinical Pulmonary Medicine
关键词
肺结核
药物性肝损害
乙型肝炎病毒
pulmonary tuberculosis
drug-induced liver injury
hepatitis B virus
