摘要
目的观察慢性乙型肝炎合并肺结核应用恩替卡韦治疗的临床效果。方法收集62例慢性乙型肝炎合并肺结核患者作为研究对象,就诊时间为2014年1月~2016年7月,随机分为观察组和对照组各31例,两组均使用相同的抗结核初治方案,此外,观察组使用恩替卡韦片治疗。比较两组治疗前后肝功能指标及HBV-DNA水平。结果肝功能指标:治疗后两组ALB、ALT、TBIL水平均明显降低,与治疗前比较,差异有统计学意义(P<0.05),治疗后观察组ALB、ALT、TBIL水平与对照组比较更低,两组差异有统计学意义(P<0.05)。HBV-DNA水平:治疗后两组HBV-DNA水平均明显降低,与治疗前比较,差异有统计学意义(P<0.05),治疗后观察组HBV-DNA水平与对照组比较更低,两组差异有统计学意义(P<0.05)。结论恩替卡韦对慢性乙型肝炎并肺结核患者肝功能有显著的改善作用,可显著抑制病毒复制,建议在慢性乙型肝炎合并肺结核患者中推广应用。
Objective To observe the clinical efficacy of the application of entecavir in the treatment of chronic hep- atitis B complicated with pulmonary tuberculosis. Methods A total of 62 patients with chronic hepatitis B complicated with pulmonary tuberculosis were collected as the research subjects. They were diagnosed from January 2014 to July 2016. They were randomly assigned to the observation group and the control group, with 31 patients in each group. Both groups were given the same initial treatment protocol of anti-tuberculosis. In addition, the observation group was given entecavir tablets. The liver function indices and HBV-DNA level between two groups were compared before and after the treatment. Results Liver function indices： ALB, ALT and TBIL levels were significantly de~＇rcased in both groups after the treatment, and the differences were statistically significant compared with those bei＇~,t~： the treatment （P〈0.05）. ALB, ALT and TBIL levels in the observation group after the treatment were even lower than those in the control group, and the differences between the two groups were statistically significant （P〈0.05）. HBV-DNA level： HBV-DNA level in both groups after thetreatment was significantly decreased, and the difference was statistically sig- nificant compared with that before the treatment （P〈O.05）. HBV-DNA level in the observation group after the treatment was even lower than that in the control group, and the difference between the two groups was statistically significant （P〈O.05）. Conclusion Entecavir has a significant improving effect on the liver function in the patients with chronic hepatitis B complicated With pulmonary tuberculosis, which can greatly inhibit the replication of virus. It is suggested that the application of entecavir be popularized in the patients with chronic hepatitis B complicated with pulmonary tu- berculosis.
出处
《中国现代医生》
2017年第14期97-99,共3页
China Modern Doctor
关键词
慢性乙型肝炎
肺结核
恩替卡韦
肝功能
Chronic hepatitis B
Pulmonary tuberculosis
Entecavir
Liver function
