摘要
目的 增强对小细胞肺癌合并Lambert Eaton综合征的认识。方法 回顾性分析我院小细胞肺癌合并Lambert Eaton综合征的病例资料。结果 Lambert Eaton综合征的肌电图特征为外周神经在低频重复电刺激下动作电位波幅递减 ,在高频电刺激下波幅递增。在 332例经病理确诊的小细胞肺癌中 ,有 10例经肌电图确诊为Lambert Eaton综合征 ,比例为 3 .0 %。其中男性 9例 ,女性 1例 ,平均年龄为 5 7.6岁± 4.9岁 ( x±s) ,9例年龄在 5 0～ 6 9岁。除 1例外 ,所有患者均在肺癌诊断前 2个月至 36个月 (中位数 :6个月 )即出现肌无力症状 ,症状以双下肢肌无力为主。小细胞肺癌合并Lambert Eaton综合征的治疗主要针对小细胞肺癌本身。结论 由于肌无力症状的出现常早于小细胞肺癌的诊断 ,增加对Lambert Eaton综合征的认识将有助于尽早发现小细胞肺癌 。
Objective To enhance the acknowledgement of LambertEaton syndrome in patients with small cell lung cancer. Methods Retrospective case analysis of LambertEaton syndrome in patients with small cell lung cancer in our hospital. Results The characteristics of electromyography for LambertEaton syndrome was reduction in action potential amplitude after repetitive peripheral nerve stimulation at low frequency and increased amplitude at high frequency. There were 10 cases of LambertEaton syndrome in 332 pathologically diagnosed small cell lung cancer, 9 male and 1 female with an average age of 57.6±4.9. Nine of 10 cases were among 50 to 69. All patients except one experienced myasthenia, mainly in lower extremities, 2 to 36 months (median: 6 months) before the diagnosis of small cell lung cancer. Treatment of small cell lung cancer may improve the symptoms of LambertEaton syndrome.Conclusion Improving the recognition of LambertEaton syndrome may be helpful to identify early small cell lung cancer and improve the prognosis, as the symptom of muscular weakness usually appears early before the diagnosis of small cell lung cancer.
出处
《中国肺癌杂志》
CAS
2000年第5期363-365,共3页
Chinese Journal of Lung Cancer
