摘要
目的：建立GC法测定复方双七胶囊中龙脑的含量。方法：以水杨酸甲酯为内标，乙酸乙酯为溶剂，HP-INNOWAX毛细管柱（0．25μm×0．25mm×30m）为色谱柱，氮气为载气，柱温170℃，进样器和氢火焰离子化检测器温度均为230℃。结果：樟脑、异龙脑、龙脑与内标在所建立的色谱条件下获得良好分离，龙脑在0．1—4．0g-L-1 r=1．0000）范围内线性关系良好，平均加样回收率为101．0％（RSD=1．58％，n=9），样品中的樟脑与异龙脑均未超过限度。结论：该方法简便、准确，可用于复方双七胶囊的质量控制。
Objective： To establish a GC method for determination of borneol in compound Shuang-Qi capsules. Method： Methyl salicylate and ethyl acetate were used as the internal standard and solvent, respectively. The HP-INNOWAX capillary column（0. 25 μm × 0. 25 mm× 30 m） was used for the separa- tion, with nitrogen as the carrier gas and FID as the detector. The column temperature was set at 170 ℃, and the injector and detector temperatures were both set at 230 ℃. Results： Camphor, isoborneol, borneol and the internal standard were separated well under the established GC condition. The linear range of borneol was 0. 1 -4. 0 g-L-1, r = 1. 000 0）. The average recovery rate of borneol was 101.0% （ RSD = 1.58%, n = 9）. The content of neither camphor nor isoborneol exceeded their respective limits. Conclusion： The method is convenient and accurate. It can be used for the quality control of borneol in compound Shuang-Qi capsules.
出处
《药学进展》
CAS
2013年第8期403-406,共4页
Progress in Pharmaceutical Sciences
