摘要
目的:探讨抑郁症患者海马生化代谢及其与疗效的关系。方法:对13例未服药的抑郁症患者(抑郁症组)及13位健康志愿者(对照组)海马行多体素氢质子磁共振波谱(1H-MRS)扫描。经6周抗抑郁治疗后,抑郁症组再次行1H-MRS扫描。测定两组海马N-乙酰天门冬氨酸(NAA)、谷氨酸-谷氨酰胺复合物(Glx)、胆碱复合物(Cho)、肌醇、肌酸等化合物的含量,并分析其与疗效的关系。结果:治疗前抑郁症组左侧海马NAA值为0.93±0.21,右侧为0.96±0.19;对照组左侧海马NAA值为1.36±0.27,右侧为1.37±0.25;两组对应侧相比,差异有统计学意义(P均=0.000)。比较治疗前后两组间左右两侧海马Glx、Cho、肌醇含量,差异无统计学意义(P均>0.05)。治疗前与治疗后海马各生化指标的变化值与HAMD评分减分值之间无明显相关性。结论:抑郁症患者海马生化代谢异常可能与抑郁症的发生有关。
Objective： To explore the neurochemical characteristics and correlates of hippocampus metabolites in patients with major depressive disorder.Methods： Thirteen unmediated patients meeting the DSM-Ⅳcriteria for depression disorder（depression group）,and 13 psychiatrically normal matched comparison subjects（control group） were included in the study.Proton magnetic resonance spectroscopy（1H-MRS） was used to determine the levels of N-acetylaspartate（NAA）,glutamate/glutamine（Glx）,choline compounds（Cho）,myoinositol,and creatine（Cr） in hippocampus of all 26 subjects.Thirteen patients underwent a second 1H-MRS examination after 6 weeks antidepressive treatment.The associations between metabolite levels and treatment effects were analysed.Results： NAA levels from bilateral hippocampus were significantly lower in depressive patients than in comparison subjects（for left,0.93±0.21 vs 1.36±0.27,P=0.000;for right,0.96±0.19 vs 1.37±0.25,P=0.000）.There were no significant differences in the concentrations of Glx、Cho、myoinositol between the two groups（P＆gt;0.05）.No significant changes in the neurochemistry were observed before and after treatment with antidepressive agents（P＆gt;0.05）.No correlations were found between the changes in the metabolite levels and treatment effects（P＆gt;0.05）.Conclusions： The abnormal changes of NAA,Glx,Cho,and mI metabolites in hippocampus may be implicated in the pathogenesis of depressive disorder.
出处
《江苏大学学报（医学版）》
CAS
2013年第2期161-164,共4页
Journal of Jiangsu University：Medicine Edition
基金
镇江市社会发展资助项目(SH2011043)
关键词
抑郁症
海马
氢质子磁共振波谱
depressive disorder
hippocampus
1H magnetic resonance spectroscopy
