摘要
目的本研究对康莱特联合化疗和单纯化疗治疗中晚期胃癌的疗效、毒副反应及对生活质量的影响加以比较。方法将96例患者随机分成两组。单纯化疗组(对照组)48例,采用DCF方案:多西他赛35 mg/m2静滴d1,d8;顺铂40 mg静滴d1～d3;氟尿嘧啶750 mg/m2,持续静脉滴注24 h,d1～d5,21天一周期。康莱特联合化疗组(实验组)48例,化疗方案同对照组,化疗第一天开始静脉滴注10%康莱特注射液200 ml,连用10天。两周期治疗结束后对疗效、毒副反应及生活质量进行评价。结果实验组有效率为52%,对照组为33%,两组比较有显著性差异(P<0.05)。两组治疗后的生活质量有显著性差异(P<0.05)。实验组的不良反应发生率低于对照组,发生程度较轻。结论康莱特联合化疗能提高有效率,降低不良反应,改善患者的生活质量。
Objective To explore the efficacy and adverse effects of chemotherapyusing kanglaitecombined with DCF and use DCF alone on the treatment advanced gastric cancer,and the effects on life quantity for patients with gastric cancer.Methods 96 patients with advanced gastric cancer were divided into two groupsrandomly.Patients（n = 48） incontrol groupused DCF treatment program which includingintravenously Docetaxel 35mg / m2at day1 and day8,intravenously cisplatin 40mg at day1 ～ 3,continuously infusion of fluorouracil 750 mg / m2for 24h at day1 ～ 5,3 weeks for a cycle.Patients in experimental group（n = 48） received the program of DCF combined with kanglaite,200ml kanglaitewas given intravenous at the concentration of 10% at the first 10daysfor each chemotherapy cycle.Evaluate the efficacy,toxicity and survival quality.Results Efficiency for experimental group（52%） was significantly higher than thatfor the control group（33%）（P 0.05）.The difference of life quality between the two groups was statistically significant（P 0.05）.The incidence of adverse reaction in experimental group was lower than that in control group.Conclusions Kanglaite combined with DCF could improve the efficiency,reduce the adverse reactions and improve the life quality for gastric cancer patients receivedchemotherapy.
出处
《齐齐哈尔医学院学报》
2013年第16期2343-2345,共3页
Journal of Qiqihar Medical University
关键词
胃癌
康莱特
联合化疗
Gastric cancer
Kanglaite
Combined chemotherapy
