摘要
目的探讨多药耐药菌感染患者的原因、相关因素,并采取相应的措施以控制感染的发生,降低感染率。方法选取2010年1月-2012年12月50例多药耐药菌感染患者为研究对象,根据不同住院年份分成两组,2010年1月-2011年6月20例多药耐药菌感染病例为对照组,2011年7月-2012年12月30例多药耐药菌感染病例为观察组,比较两组在病原菌以及易感因素的差异性。结果对照组的多药耐药菌细菌感染率为5.6%,观察组为7.3%,且两组多药耐药菌感染均以下呼吸道、泌尿道感染及切口感染为主,病原菌以大肠埃希菌、肺炎克雷伯菌、铜绿假单胞菌常见,以产超广谱β-内酰胺酶菌株最广泛;年龄>70岁、≥2种并发症、住院时间>30d、侵入性操作、使用抗菌药物>3种、使用免疫抑制剂等均是多药耐药菌感染的危险因素。结论早期监测多药耐药菌感染并予以对症处理,合理使用抗菌药物,可有效控制多药耐药菌感染的发生。
OBJECTIVE To study the causes and related factors for the multidrug-resistant bacteria infections and take corresponding measures so as to reduce the infection rate.METHODS A total of 50cases of patients with multidrug-resistant bacteria infections who were hospitalized from Jan 2010to Dec 2012were enrolled in the study and were divided into two groups according to different years,while 20cases with multidrug-resistant bacteria infections extracted from 360cases who were hospitalized from Jan 2010to Jun 2011were chosen as the control group,and 30cases with multidrug-resistant bacteria infections extracted from 410cases who were hospitalized from Jul 2011to Dec 2012were set as the observation group,then the distribution of pathogens and the predisposing factors were compared between the two groups.RESULTS The incidence rate of the multidrug-resistant bacteria infections was 5.6%in the control group,7.3%in the observation group;the lower respiratory tract,urinary tract,and surgical incision were the main infection sites.Escherichia coli,Klebsiella pneumoniae,and Pseudomonas aeruginosa were the most common species of pathogens,and the extended spectrumβ-lactamase-producing strains were dominant.The advanced age（more than 70years old）,complications（more than two types）,hospitalization duration（more than 30days）,invasive operation,use of antibiotics（more than three types）,and use of immune inhibitors were the risk factors for the multidrug-resistant bacteria infections.CONCLUSION The early monitoring of the multidrug-resistant bacteria infections,symptomatic treatment,and reasonable use of antibiotics can effectively control the multidrug-resistant bacteria infections.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2013年第16期3853-3855,共3页
Chinese Journal of Nosocomiology
基金
青海省西州科技局科技项目计划(2011-F36)
关键词
多药耐药菌
感染
相关因素
预防措施
Multidrug-resistant bacteria
Infection
Related factor
Preventive measure
