摘要
目的探讨经急诊冠脉介入(PCI)治疗的急性ST段抬高型心肌梗死(STEMI)患者血浆N末端B型利钠肽原(NT-proBNP)水平与全球急性冠状动脉事件注册(GRACE)评分的关系,分析NT-proBNP对STEMI患者近期(6个月)发生心脏不良事件(MACE)的预测价值。方法选择2008年1月—2010年12月在本院住院治疗的STEMI患者212例,入院后测定血浆NT-proBNP浓度,同时采用GRACE评分标准计算患者GRACE积分水平并进行危险分层:低危组68例,中危组78例,高危组66例;住院期间常规治疗。结果高危组lgNT-proBNP高于中危组和低危组(P<0.01),中危组lgNT-proBNP高于低危组(P<0.05)。STEMI患者的lgNT-proBNP水平与其GRACE评分呈正相关(r=0.56,P<0.01)。结论 STEMI患者NT-proBNP水平越高,GRACE积分越高,NT-proBNP的检测在STEMI早期危险性评估具有重要的临床价值。
Objective To explore the relationship between plasma N-terminal pro-brain natriuretic peptide（NT-proBNP）level and global registry of acute coronary events（GRACE） scores in patients with acute ST-segment elevation myocardial infarction who undergo primary percutaneous coronary intervention.Methods A total of 202 patients with acute ST-segment elevation myocardial infarction（STEMI） who underwent primary percutaneous coronary intervention in our hospital between January 2008 and December 2010 were involved this study.Plasma NT-proBNP level and the GRACE risk score were measured on admission.According the GRACE risk stratification,patients were divided into low-risk group,middle-risk group and high-risk group.There were 68 low-risk patients,78 middle-risk patients and 66 high-risk patients.Results Compared with middle-risk group and low-risk group,lgNT-proBNP level was significantly higher in high-risk group（P〈0.01）,and the level of middle-risk group was significantly higher（P〈0.01）.lgNT-proBNP was positively correlated with GRACE risk score（r=0.56,P〈0.01）.Conclusion On admission plasma NT-proBNP level parallels GRACE risk score in STEMI patients,and NT-proBNP has clinical value to risk evaluation in STEMI patients.
出处
《实用临床医药杂志》
CAS
2013年第11期15-17,共3页
Journal of Clinical Medicine in Practice
