摘要
随着年龄增长,男性性腺功能减退,睾酮水平随之下降。近年来国外开展的大规模流行病学调查、基础及临床研究显示,生理水平的睾酮对维持心血管系统正常功能起重要作用。睾酮缺乏可引起高血脂、高血糖、高血压、凝血与纤溶失衡及炎症等心血管疾病危险因素的发生,导致血管内皮功能障碍,影响血管的舒缩功能,加速动脉粥样硬化形成,增加心血管疾病发生的风险。
Serum testosterone levels and gonad function decline with the aging of males. Large-scale epidemiological investigations, mechanism researches and clinical studies conducted in recent years have shown that physiological androgens are critical for the protection of the cardiovascular system. Testosterone deficiency in aging males is associated with several cardiovascular risk factors which include hyperlipidemia, diabetes, hypertension, thrombogenic and fibrinolytic dysfunction and inflammation. It can also lead to endothelial and vascular dysfunction, accelerate the formation of atherosclerosis and increase the morbidity of cardio-vascular disease.
出处
《中华男科学杂志》
CAS
CSCD
2013年第8期742-747,共6页
National Journal of Andrology
基金
国家“十二五”科技支撑计划(2012BAI32B00)~~
关键词
睾酮缺乏
心血管疾病
危险因素
中老年男性
testosterone deficiency
cardiovascular disease
risk factors
aging male
