摘要
目的:对比观察两种剂量的辛伐他汀治疗急性脑梗死的临床疗效,以探讨合适的剂量。方法:选取2009年2月-2012年2月笔者所在医院收治的120例脑梗死患者,将其随机分为观察组和对照组,各60例。两组在给予常规治疗的基础上,观察组另外加用辛伐他汀40mg/d,对照组加用辛伐他汀20mg/d,疗程均为4周。对比观察两组患者的神经功能缺损情况及治疗疗效。结果:治疗结束后,两组患者神经功能缺损程度评分均有所改善,观察组神经功能缺损评分为(13.8±7.0)分,对照组为(16.6±7.1)分,两组神经功能缺损评分比较差异具有统计学意义(P<0.05)。而在治疗疗效方面,观察组总有效率(98.0%)高于对照组(78.0%),且两组总有效率比较差异有统计学意义(P<0.05)。结论:大剂量辛伐他汀较常规剂量治疗急性脑梗死具有较好临床疗效,且未发现明显不良反应,值得临床推广应用。
Objective To study the clinical value of Benazepril and Simvastatin in the treatment of diabetic nephropathy. Methods 120 patients with diabetic nephropathy admitted in our hospital from October, 2008 to July, 2012 were selected as the research object, and they were divided into the observation group（n=60） and the control group （n=60） randomly. Patients of the observation group were given Benazepril and Simvastatin, while the control group were only given Benazepril. Renal functions of the two groups were detected after the treatment for four weeks. Results The values of Scr, Urea and 24h urinary protein of the observation group were lower than those of the control group, and the value of Ccr was significantly higher than that of the control group. Conclusion Benazepril combined with Simvastatin treatment has positive clinical value for it can effectively improve the renal functions.
出处
《中外医学研究》
2013年第23期27-27,共1页
CHINESE AND FOREIGN MEDICAL RESEARCH
关键词
辛伐他汀
急性脑梗死
剂量
Diabetic nephropathy
Benazepril
Simvastatin
