摘要
目的探讨阿托伐他汀钙对脑血管病患者的抗动脉粥样硬化及稳定斑块的作用。方法选择缺血性脑血管病患者100例,均经颈动脉超声证实其颈动脉内有斑块形成。给予阿司匹林(商品名,拜阿司匹林)0.1g/d。在此基础上,分为阿托伐他汀钙组(治疗组)50例,服用阿托伐他汀钙20mg/d,持续6个月;对照组50例,未给予阿托伐他汀钙治疗。分别于治疗前、治疗后3和6个月检测血脂,用颈动脉超声检测患者的双侧颈动脉内-中膜厚度(IMT)、斑块形态等指标。结果①治疗组服药3个月时,低密度脂蛋白胆固醇(LDL-C)和三酰甘油(TG)分别为(3.1±0.8)和(1.1±0.8)mmol/L,与对照组[(3.4±0.8)和(1.7±0.7)mmol/L]同时间点比较,差异有统计学意义(P<0.05,P<0.01);治疗组和对照组服药6个月时,总胆固醇(TC)为(4.3±0.9)、(5.6±0.8)mmol/L、LDL-L为(3.0±0.5)、(3.4±0.8)mmol/L、高密度脂蛋白胆固醇(HDL-C)为(1.1±0.2)、(1.0±0.3)mmol/L及TG为(1.1±0.9)、(1.6±0.3)mmol/L,两组同时间点比较,差异均有统计学意义(均P<0.05)。②治疗组和对照组6个月时,IMT分别为1.0±0.4和1.1±0.2,Crouse斑块积分分别为1.0±0.6和1.1±0.5,两组比较,差异有统计学意义(均P<0.05)。结论服用阿托伐他汀钙在短期内即可起到降脂作用,服药6个月以上可减轻缺血性脑血管病患者颈动脉粥样硬化程度,同时能够稳定斑块。
Objective To investigate the effects of atorvastatin calcium on carotid atherosclerosis and the stability of plaques in patients with ischemic cerebrovascular disease. Methods One hundred pa- tients with ischemic cerebrovascular disease were selected, and they were divided into atorvastatin calcium （20 mg/d） group （treatment group, n =50） and control group （without atorvastatin calcium, n = 50）. Blood lipids were detected before, and 3,6 months after the treatment. The intima-media thickness （IMT） of bilateral carotid arteries and plaque morphology were evaluated with carotid ultrasound examination. Results （1）Low density lipoprotein cholesterol （ LDL-C ） and triacylglycerol （ TG ） at 3 months in the treatment group were 3.1 ± 0.8 and 1.1 ± 0.8 mmol/L, respectively. As compared with the control group （3.4 ± 0.8 and 1.7 ± 0.7 mmol/L） at the same time point, there were significant differences （P 〈 0.05, P 〈0.01 ） ; Total cholesterol （ TC）, LDL-L, high density lipoprotein cholesterol （HDL-C） and TG at 6 months in the treatment group were 4.3 ± 0.9, 3.0 ± 0.5, 1.11 ± 0.23 and 1.1 ± 0.9, respectively. As compared with the control group at the same time point, there were significant differences （P 〈 0.05 ）. （2）The ITM in the treatment and control groups at 6 month were 1.0 ± 0.4 and 1. 1 ± 0.2, respectively. Crouse integrals in plaque were 1.0 ± 0.6 and 1.1 ± 0.5, respectively. There were significant differences between the 2 groups （ P 〈 0.05 ）. Conclusion Atorvastatin calcium may play a lipid-reducing effect in a short term, it can reduce the severity of carotid atherosclerosis in patients with ischemic cerebrovascular disease, and stabilize the plaques simultaneously.
出处
《中国脑血管病杂志》
CAS
2008年第9期390-394,共5页
Chinese Journal of Cerebrovascular Diseases
关键词
颈动脉疾病
药物疗法
阿托伐他汀钙
Carotid artery diseases
Drug therapy
Atorvastatin calcium
