摘要
目的 探讨非小细胞肺癌 (NSCLC)组织中基质金属蛋白酶 2 (MMP 2 )和基质金属蛋白酶 9(MMP 9)的表达水平及其预后意义。方法 采用免疫组化SP法检测 2 8例正常肺组织、3 2例癌旁异型增生肺组织和 62例NSCLC组织中MMP 2和MMP 9的表达水平。结果 NSCLC组织中MMP 2 ( 77.4% )和MMP 9( 80 .6% )阳性表达率均显著高于癌旁异型增生组织和正常肺组织 (P均 <0 .0 0 5 )。腺癌和腺鳞癌中MMP 2和MMP 9阳性表达率均显著高于鳞癌 (P均 <0 .0 5 )。MMP 2和MMP 9的阳性表达率随TNM分期而增加 ,Ⅲ +Ⅳ期显著高于Ⅰ +Ⅱ期 (P <0 .0 2 5 ,P <0 .0 5 )。有淋巴结转移者MMP 2和MMP 9阳性表达率高于无淋巴结转移者 (P <0 .0 0 5 ,P <0 .0 5 )。生存 1、3年的患者MMP 2和MMP 9阳性表达率均高于 5年以上存活者 (P <0 .0 5 ,P <0 .0 0 5 )。结论 NSCLC组织内MMP 2和MMP 9阳性表达可能是预测肿瘤恶性行为的有用指标。
Objective To determine the expression of MMP 2 and MMP 9 in non small cell lung cancer (NSCLC) tissues and their prognostic value. Methods The expression of MMP 2 and MMP 9 were detected in 62 NSCLC tissues by immunohistochemical method, and 28 normal lung tissues and 32 para cancerous dysplastic lung tissues as control. Results The expression levels of MMP 2(77.4%,48/62) and MMP 9(80.6%,50/62)in the NSCLC tissues were significantly higher than those in the control groups(P<0.005,P<0.005). The positive rates of MMP 2 and MMP 9 in adenocarcinoma and adenosquamous carcinoma were remarkably higher than those in squamous cell carcinoma(P<0.005, P<0.05), were much higher in stage Ⅲ+Ⅳ group than those in stage Ⅰ+Ⅱ group (P<0.025,P<0.05), and were significantly higher in tumors with lymph node metastasis than those without lymphatic metastasis (P<0.005,P<0.05). The patients surviving for 1 and 3 year had much higher MMP 2 and MMP 9 expression rates than those surviving for over 5 year (P<0.05,P<0.005). Conclusion MMP 2 and MMP 9 expression in NSCLC tissues might be indicators of tumor behavior.
出处
《中国肺癌杂志》
CAS
2000年第2期107-110,共4页
Chinese Journal of Lung Cancer
