摘要
目的综合评价血清基质金属蛋白酶-9(MMP-9)与其它肿瘤标记物-癌胚抗原(CEA)、神经元特异性烯醇化酶(NSE)、糖类抗原125(CA125)和糖类抗原19-9(CA19-9)等对非小细胞肺癌诊断及预测疾病状态的临床意义。方法利用ELISA方法和多肿瘤标记物蛋白芯片检测系统分别测定73例非小细胞肺癌患者、21例良性肺疾病患者以及16例健康人体血清中MMP-9、CEA、NSE、CA125和CA19-9的水平,比较5项指标对非小细胞肺癌诊断的灵敏度和特异度。结果非小细胞肺癌患者血清中MMP-9、CEA、NSE、CA125和CA19-9的水平均显著高于良性肺疾病组和健康组(P<0.01),其中血清MMP-9检测对诊断非小细胞肺癌的灵敏度较高。另外,MMP-9的水平随肿瘤体积增大、淋巴结转移以及临床分期进展而显著升高(P<0.01)。结论血清MMP-9与CEA、NSE、CA125和CA19-9对非小细胞肺癌诊断都具有一定的临床价值,血清MMP-9还是一项预测非小细胞肺癌侵袭、转移等疾病状态的良好指标。
Objective To evaluate the application of MMP-9 and other four tumor markers in serum in diagnosing non-small cell lung cancer （NSCLC） and their correlation with the clinical stage of NSCLC. Methods Using the ELISA method and tumor markers protein chip,the serum levels of MMP-9, CEA, NSE,CA125 and CA19-9 in 73 cases of NSCLC ,21 cases of benign pulmonary disease and 16 cases of normal controls were measured and compared among the three groups of the cases. In addition, the sensitivity and specificity of MMP-9, CEA, NSE,CA125 and CA19-9 were evaluated. Results The concentrations of serum MMP-9, CEA, NSE,CA125 and CA19-9 in the patients with NSCLC were significantly higher than those in the group with benign lung disease and in the control group （P 〈0.01）. The sensitivity of serum MMP-9 in diagnosing NSCLC was relatively higher. Moreover,the levels of MMP-9 remarkably went up in NSCLC patients with increase in tumor size, lymph node metastasis and clinical stage development （P 〈 0.01 ）. Conclusion The serum levels of MMP-9 ,CEA, NSE,CA125 and CA19-9 were much valuable in diagnosis of NSCLC. Furtbermore,tbe serum MMP-9 would also be a good marker for the invasion, metastasis and status of NSCLC.
出处
《临床内科杂志》
CAS
2006年第5期331-333,共3页
Journal of Clinical Internal Medicine
