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老年糖尿病患者血清胰岛素样生长因子-1的测定及其与脂质代谢的相关性分析

Determination of Serum Insulin-like Growth Factor-1 (IGF-1) and the Analysis of the Correlation between its Level and Lipid Metabolic Disorder in Aged Diabetes
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摘要 目的 :为了探讨老年糖尿病患者血清胰岛素样生长因子_1(IGF_1)水平与脂质代谢紊乱的关系。方法 :检测 6 0例老年糖尿病患者血清IGF_1、血糖、胰岛素、生长激素、总胆固醇、甘油三酯、高密度脂蛋白胆固醇及低密度脂蛋白胆固醇水平 ,并与 30名正常健康成年人、50名正常健康老年人作比较 ,同时还分析了血清IGF_1水平与其余各项指标的相关性。结果 :(1)正常老年人血清IGF_1水平明显低于正常成年人 (P <0 .0 1) ;(2 )老年糖尿病组IGF_1水平远远低于两对照组 (P <0 .0 1) ;(3)除了HDL_C外 ,老年糖尿病组所有检测血脂指标都高于正常对照组 (老年 ) ;(4 )老年糖尿病组IGF_1水平与胰岛素、生长激素呈明显正相关 (P <0 .0 5) ,与葡萄糖、总胆固醇、甘油三酯、低密度脂蛋白胆固醇呈明显负相关 (P <0 .0 1) ,与高密度脂蛋白胆固醇无相关性 (P>0 .0 5)。结论 :以上结提示 ,老年糖尿病患者血清IGF_1水平与脂质代谢紊乱密切相关。 To investigate the correlation between serum IGF_1 level and the disorder of lipid metabolism in aged diabetes. Method:Serum levels of IGF_l,glucose(Glu),insulin(Ins),growth hormone(GH),total cholesterol(T_ch),triglyceride(TG),high density lipoprotein cholesterol (HDL_c) and low density lipoprotein cholesterol (LDL_c) in 60 cases of aged diabetes were detected,and were compared with that in 30 cases of healthy adults (25-58 years old)and that in 50 cases of healthy aged control (6l-90 years old).Meanwhile the correlations of serum IGF_1 with other indexes were also analysed.Results:(l)Serum IGF_1 level in aged healthy control was obviously lower than that in healthy adults ( P <0.01). (2)IGF_1 level in aged diabetes group was remarkably lower than that in the two groups of normal controls ( P <0.001). (3)The levels of all blood_lipid related indexes except HDL_c (i.e.T_ch,TG and LDL_c) in aged diabetes group were significantly higher than that in the aged healthy control (P<0.01). (4) In aged biabetes group,the serum IGF_1 level was positively correlated with Ins and GH level (P<0.05) and negatively correlated with Glu,T_ch,TG and LDL_c level (P<0.01),but without correlation with HDL_c level (P>0.05). Conclusion:Based on the above results,it could be concluded that there is a close relationship between the change of serum IGF_1 and the disorder of lipid metabolism in aged diabetes.
出处 《广州医学院学报》 2000年第1期24-27,共4页 Academic Journal of Guangzhou Medical College
关键词 IGF-1 糖尿病 脂质代谢 相关因素 老年人 Insulin-like growth factor-1 Aged diabetes Lipid metabolism Correlated factors
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参考文献8

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