摘要
目的:观察用苯那普利治疗老年原发性高血压(EH)患者6个月前后血清胰岛素样生长因子-1 (IGF-1)的水平及左室质量指数(LVMI)的变化。方法:用放射免疫法检测EH患者40例(EH组)和老年健康者36例(NC组)血清IGF-1水平,以超声测定2组的LVMI,并观察EH组用苯那普利治疗6个月前后二者的改变。结果:EH组血清IGF-1水平为(207.70±79.21)μg/L,明显高于NC组(132.53±35.62)μg/L(P<0.01);LVMI 分别为150.67±25.48、101.32±13.56(P<0.05)。苯那普利治疗6个月后,血清IGF-1水平降至(156.82±36.40)μg/L(P<0.01),LVMI下降至112.01±22.34(P<0.05)。结论:EH组患者血清IGF-1及LVMI水平升高,苯那普利治疗可使IGF-1水平降低,并逆转左室肥厚。
Objective： To evaluate the changes of serum insulin-like growth factor-1（IGF-1）and left ventricular mass index（LVMI） in elderly patients with essential hypertension（EH） before and after 6 months treatment by Benazepril. Method：Forty elderly patients suffering from EH （EH group）and 36 healthy elderly people （NC group） were selected. The serum IGF-1 level was measured by immunoradiometry and LVMI was determined by echocardiography. Result：Compared with NC group [（132.53±35. 62）ng/ml], the level of IGF-1 in EH group [（207.70±79.21） ng/ml] was significantly higher （ P〈0.01） ;The levels of LVMI were （150.67±25.48）kg/ m^2, （101.32±13.56）kg/m^2 respectively （P〈0.05）. After 6 months treatment by Benazepril, IGT-1 was reduced to （156.82±36.40）ng/ml （ P 〈0.01） while LVMI was decreased to （112.01±22.34）kg/m^2 （ P 〈0.05）. Conclusion： The elderly patients with EH exist the high levels of IGT-1 and LVMI. Benazepril can decrease IGT-1 and regress left ventricular hypertrophy.
出处
《临床心血管病杂志》
CAS
CSCD
北大核心
2005年第9期522-524,共3页
Journal of Clinical Cardiology
关键词
高血压
苯那普利
胰岛素样生长因子1
左心室肥厚
Hypertension
Benazepril
Insulin-like growth factor-1
Left ventricular hypertrophy
