摘要
目的:探讨鼻用糖皮质激素对儿童阻塞性睡眠呼吸暂停低通气综合征(obstructive sleep apnea hypopnea syndrome,OSAHS)的治疗效果。方法:符合条件的OSAHS患儿96例,根据多导睡眠监测结果分成轻度OSAHS组32例,中重度OSAHS组64例。所有患儿经鼻用糖皮质激素喷鼻,连续用药1月以上,1月后进行多导睡眠监测复查。结果:轻度OSAHS组睡眠呼吸监测呼吸暂停低通气指数(AHI)经鼻用糖皮质激素喷鼻剂治疗1月后由治疗前的8.43±1.32降低为治疗后的3.23±1.32,差异有统计学意义(P<0.05);中重度OSAHS组治疗前AHI为26.32±8.56,治疗后为17.32±4.22,差异无统计学意义(P>0.05)。结论:鼻用糖皮质激素对儿童OSAHS治疗有一定疗效,尤其对于轻度OSAHS患儿,对于中重度OSAHS患儿疗效不显著。
Objective： To study the effect of intranasal glucocorticoids in the treatment of obstructive sleep apnea hypopnea syndrome in children.Metheds： Ninety-six children with obstructive sleep apnea hypopnea syndrome were divided into two groups on the basis of polysomnography（PSG）.Thirty-two patients were in the mild group and sixty-four patients in the moderate to severe group.All were treated with intranasal glucocorticoids for one month.After one month,all patients were reexamined PSG.Results： One month after treatment,the AHI of the mild group was reduced to 3.23±1.32 from 8.43±1.32,the difference was significant（P0.05）.The moderate to severe group reduced to 17.32±4.22 from 26.32±8.56,there were no distinctive differences between before and after the treament.Conclusions： Intranasal glucocorticoids have effects in the treatment of OSAHS in children,especially in the mild group,and with poor effects in the moderate to severe group.
出处
《儿科药学杂志》
CAS
2013年第7期10-12,共3页
Journal of Pediatric Pharmacy
基金
深圳市科技计划项目(医疗卫生类201102077)
