摘要
目的观察支原体肺炎患儿T细胞亚群水平的变化，探讨其在支原体肺炎发病中的作用，为肺炎支原体肺炎的免疫治疗提供临床依据。方法采用病例对照研究的方法。选择2010年1—12月在本院确诊为支原体肺炎的患儿共25例作为病例组，对照组为同期健康体检儿童共15例。分别检测两组患儿T淋巴细胞亚群指标。结果支原体肺炎患儿外周血CD3＋、CD4＋、CD4＋／CD8＋T细胞百分率较对照组低，两组间差异有统计学意义（P〈0．05）。而两组间CD8＋百分率差异无显著性。结论支原体肺炎时存在免疫功能失调，免疫调节剂在肺炎支原体治疗中十分必要的。
Objective The study was designed to observe the changes of the levels of Tlymphocyte subsets in the mycoplasma pneumonia,and to explore the possibility of immunotherapy of patients with mycoplasma pneumonia. Methods Twenty-five patients with mycoplasma pneumonia and 15 age-matched control subjects participated in a case control experimental study from January 2010 to December 2010.T lymphocyte subsets were detected respectively. Results The percentage of CD3＋,CD4＋ and CD4＋/CD8＋ in MP group was lower than that in control group （P 〈 0.05）.However, the percentage of CD8＋ was no significant difference between the kiP and control group. Conclusion Unbalance cell-mediated immunity may play an important role in the pathogenesis of mycoplasma pneumonia.Immunomodulators may be an efficient treatment of mycoplasma pneumonia.
出处
《中国医药科学》
2013年第15期213-214,共2页
China Medicine And Pharmacy
关键词
支原体肺炎
儿童
免疫功能
Mycoplasma pneumonia
Children
Immune function
