摘要
目的观察氟西汀对缺血性脑卒中患者血清脑源性神经营养因子(brain-derived neurotrophic factor,BDNF)的影响。方法将60例缺血性脑卒中的患者随机分为氟西汀组和安慰剂组,两组患者均同时接受物理治疗。采用酶联免疫吸附法(ELISA)测定两组缺血性脑卒中患者治疗前后BDNF的变化,并与正常对照组比较;用改良Barthel指数(modified Barthel index,MBI)和简化Fugl-Meyer运动功能量表(Fugl-Meyer assessment,FMA)评定两组患者的日常生活活动能力(activties of daily living,ADL)和运动功能。结果治疗3m后,氟西汀组BDNF浓度显著高于治疗前及安慰剂组、对照组(P<0.05);治疗后两组MBI及FMA两项评分均有改善(P<0.05),且氟西汀治疗组疗效优于对照组(P<0.05)。结论缺血性脑卒中患者早期给氟西汀和物理治疗后可促进其运动功能的恢复,提高日常生活活动能力,这种效应可能是通过提高BDNF的浓度,促进神经元再生和对抗神经元损伤后凋亡而发挥作用。
Objective To observe the effect of Fluoxetine on BDNF expression in stroke patients.Methods 60 patients with ischemic stroke which were given physiotherapy were divided randomly into Fluoxetine group and control group.Their living and motor function were all assessed with modified Barthel index and Fugl-Meyer assessment.The expression of BDNF were examined using ELISA.Results Both the scores of MBI and FMA of two groups were improved（P 0.05）.However,the Fluoxetine group improved to a greater extend than the control group（P 0.05）.Compared to the control group,the concentration of the Fluoxetine BNDF were drastically improved after treatment（P 0.05）.Conclusion Giving Fluoxetine and physiotherapy to the stroke patients in a early stage can significantly improve the motor and living function.This improvement is probably induced by increasing the concentration of BNDF,promoting neuronal regeneration and resisting apoptosis after neural lesion.
出处
《中风与神经疾病杂志》
CAS
CSCD
北大核心
2013年第7期622-624,共3页
Journal of Apoplexy and Nervous Diseases
基金
江苏省无锡市科技发展计划项目(CSZ00N1123)
