摘要
目的:考察炉甘石原料(饮片)中氧化锌含量控制的范围,补充洗剂中苯酚质量控制的内容,完善炉甘石洗剂质量控制的方法。方法:采用EDTA络合滴定法测量不同厂家不同批号的炉甘石(饮片)中氧化锌的含量,从而确立洗剂中氧化锌含量限度范围;分别采用紫外分光光度法、溴量法测定洗剂中的苯酚含量,并行方法学验证,建立洗剂中苯酚的质量标准结果:炉甘石(饮片)中氧化锌的平均含量为70.35%。紫外分光光度法测得炉甘石硫洗剂中苯酚平均回收率为101.65%,RSD为0.89%(n=6),含酚炉甘石洗剂中苯酚平均回收率为102.06%,RSD为1.64%(n=6);溴量法测得炉甘石硫洗剂中苯酚平均回收率为98.15%,RSD为0.98%(n=6),含酚炉甘石洗剂中苯酚平均回收率为98.15%,RSD为1.08%(n=6)结论:含酚炉甘石洗剂中氧化锌的含量下限为13.4%(g·ml^(-1));炉甘石硫洗剂中氧化锌的含量下限为10.6%(g·ml^(-1))溴量法简便,快速,准确,可作为洗剂中苯酚的含量测定方法。
To investigate the concentration control range of zinc oxide in the raw materials and explore the quality control method for phenol to improve the quality control of calamine lotions.Method：The zinc oxide concentration in calamine raw materials produced by different manufacturers with different batches was determined by EDTA compleximetry,and the concentration limils of zinc oxide were established.UV-spectrophotometry and bromometry were used to assay the phenol concentration in the lotions,and the methodology test was used to establish the quality standard of phenol.Result：The average zinc oxide concentration in calamine raw materials was 70.35%.The average recovery of phenol in calamine and sulfur lotions was 101.65%（RSD - 0.89%,n = 6）,while 102.06%（RSD = 1.64%,n =6） in calamine lotions delected by UV-spectrophotometry.The average recovery of phenol in calamine and sulfur lotions was 98.15%（RSD =0.98%,n =6）,while 98.15%（RSD = 1.08%,n=6） in calamine lotions detected by bromometry. Conclusion：The lower limit of the zinc oxide concentration in calamine lotions is 13.4%（g·ml^（-1） ）,while 10.6%（g·ml^（-1） ） in calamine and sulfur lotions.Bromometry is simple,rapid and accurate,and suitable for the determination of the phenol concentration in the lotions.
出处
《中国药师》
CAS
2013年第7期1012-1014,共3页
China Pharmacist
关键词
炉甘石
氧化锌
苯酚
质量控制
Calamine
Zinc oxide
Phenol
Quality control
