摘要
目的:改善复方穿心莲颗粒的口感,研究适合儿童服用的掩味混悬颗粒制备工艺。方法:采用流化床底喷工艺制备掩味颗粒,以脱水穿心莲内酯溶出度检测与口感打分、沉降容积为指标,评价掩味混悬颗粒的掩味效果。结果:尤特奇E100作包衣材料,对复方穿心莲颗粒有很好的掩味效果,制备的掩味混悬颗粒在水中分散均匀,口感良好。结论:颗粒包衣工艺掩味效果佳,制备的掩味混悬颗粒适合儿童患者服用。
Objective：This research aims to improve the taste of andrographitis compound particle,and to research the preparation technology of taste masking suspension particle which suits children.Method：Particle coating was applied to prepare taste masking particle,through building the relation of concentration with mouth taste and dissolution of dehydroandrographolide of two inspection methods to evaluate the effect of taste masking.On the basis of taste masking,the suspension of taste masking particle was prepared that can be taken by children suitably.Result：Eudragit E100 coating is good for tasting masking.The suspension particles made with the method of coating dispersed in water evenly and tasted good.Conclusion：The coating particle has good effect on taste masking.And the preparation of taste masking suspension particle is suitable for children patients to take.
出处
《中国实验方剂学杂志》
CAS
北大核心
2011年第12期12-17,共6页
Chinese Journal of Experimental Traditional Medical Formulae
基金
中医药行业科研专项(200807032)
关键词
穿心莲
掩味
颗粒包衣
混悬颗粒
andrographitis
taste masking
coating particle
suspension particle
