摘要
目的:研究楤木皂苷对大鼠肝纤维化的影响及其可能的机制。方法:采用皮下注射四氯化碳诱导大鼠肝纤维化模型,楤木皂苷给药8周,MASSON染色观察胶原纤维增生情况,检测各组大鼠肝脾指数、血清肝功能、LN、COI-Ⅲ、COI-Ⅳ的变化。结果:楤木皂苷30 mg/kg、60 mg/kg可减少肝细胞变性、坏死和纤维增生程度,改善肝功能,降低血清中LN、COI-Ⅲ、COI-Ⅳ的含量。结论:楤木皂苷对大鼠肝纤维化有防治作用,其机制可能与保护肝功能、降低血清中LN、COI-Ⅲ、COI-Ⅳ的含量有关。
Objective： To study the effects and the possible mechanisms of Aralia saponins on rats liver fibrosis.Methods：The rat model of liver fibrosis was induced by hypodermic injection of CCl4.The models were intragastric administrated by Aralia saponins for 8 weeks.collagen fibre hyperplasia was observed by MASSON staining.Liver and spleen indexes,hepatic function,serum levels of LN,COI-Ⅲ,COI-Ⅳ were detected.Results：Aralia saponins（30 mg/kg、60 mg/kg）can reduce the degeneration and necrosis of liver cells and improve hepatic function,and reduce LN,COI-Ⅲ,COI-Ⅳ in serum（P0.05）.Conclusion： Aralia saponins have preventive and therapeutic effect on rats liver fibrosis.the mechanism is related to the protection of the function of liver cells and the reduction of LN,COI-Ⅲ,COI-Ⅳ in serum.
出处
《中药药理与临床》
CAS
CSCD
北大核心
2013年第1期80-82,共3页
Pharmacology and Clinics of Chinese Materia Medica
基金
泸州医学院青年基金项目(2011027)
关键词
楤木皂苷
肝纤维化
Aralia saponins（楤木皂苷）
liver fibrosis
