摘要
目的比较伏立康唑与两性霉素B治疗急性淋巴细胞白血病合并侵入性真菌感染的疗效及安全性。方法回顾性分析60例次急性淋巴细胞白血病合并侵入性真菌感染患者,治疗组给予伏立康唑注射液4mg/kg静脉滴注,1次/12h,对照组给予两性霉素B,从小剂量开始缓慢加大剂量至1mg/kg静脉滴注,1次/d,两组均于治疗后2周评价疗效及不良反应发生率。结果治疗有效率治疗组为76.67%、对照组为46.67%,对照组不良反应消化道损害、肾功能损害、低钾血症和静脉炎发生率显著高于治疗组,对照组总不良反应发生率为73.33%,高于治疗组的26.67%,差异有统计学意义(P<0.05)。结论伏立康唑治疗急性淋巴细胞白血病合并侵入性真菌感染安全性好、疗效确切。
OBJECTIVE To compare the efficacy and safety of voriconazole and amphotericin B in the treatment of acute lymphocytic leukemia complicated with invasive fungal infections.METHODS A total of 60 cases of acute lymphocytic leukemia patients complicated with invasive fungal infections were retrospectively analyzed,the treatment group was treated with intravenous injection of voriconazole,4mg/kg,12 hours once,while the control group was given the intravenous injection of amphotericin B,by starting from the little dose to heavy dose,then to 1mg/kg,once daily;then the clinical efficacy and the incidence of adverse reactions of the two groups were evaluated two weeks after the treatment.RESULTS The effective rate was 76.67% in the treatment group,46.67% in the control group;the incidence of the adverse reactions,including the gastrointestinal damage,renal impairment,hypokalemia,and phlebitis,was 73.33% in the control group,significantly higher than 26.67% in the treatment group,the difference was significant（P0.05）.CONCLUSION Voriconazole is safer and can achieve more accurate therapeutic effect on the treatment of acute lymphocytic leukemia complicated with invasive fungal infections.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2013年第14期3494-3495,共2页
Chinese Journal of Nosocomiology
基金
国家自然科学基金(81170520)
河南省卫生厅科研课题(2011010014)
