摘要
目的探讨2型糖尿病视网膜病变(DR)患者血栓前状态标志物在早期诊断和预防DR发病中的重要作用。方法 68例DR患者为研究组,60例糖尿病无眼底视网膜病变患者作为对照组,所有患者均于晨起时抽取空腹静脉血液离心取上清液检验,二聚体(D-D)采用免疫比浊法检测,血浆纤维蛋白原(FIB)采用磁珠凝固法检测,血管性血友病因子(vWF)和内皮素-1(ET-1)采用酶联法检测,超敏C反应蛋白(hs-CRP)采用透射免疫比浊法检测。结果研究组患者DD和FIB含量检测结果明显高于对照组,比较差异有统计学意义(P<0.05);研究组患者vWF和ET-1含量检测结果明显高于对照组,比较差异有统计学意义(P<0.05);研究组患者hs-CRP检测结果明显高于对照组,比较差异有统计学意义(P<0.05)。结论 DR患者血栓前状态标志物D-D、FIB、vWF、ET-1和hs-CRP均较糖尿病无视网膜病变患者含量高,临床在诊断和预防DR发生时应注意这几项指标的变化情况。
Objective To investigate the type 2 diabetic retinopathy（DR） in patients with prothrombotic state markers an important role in the early diagnosis and prevention of DR incidence.Methods All patients were taken in the morning,fasting venous blood centrifugation supernatant inspection dimer（DD） using the detection of the immune turbidimetric method,plasma fibrinogen（FIB） using bead coagulation assay,vascular bloodFriends of the cause of the child（vWF） and endothelin-1（ET-1） using enzyme-linked assay,high sensitivity C-reactive protein（hs-CRP）,using transmission immunoturbidimetry detection.Results The detection results of the research group of patients with DD and FIB content was significantly higher,the data were statistically significant（P＆lt;0.05）.The detection results of the study group patients vWF and ET-1 levels was significantly higher than that in the control group,the data were statistically significant differences（P＆lt;0.05）.Hs-CRP test results of the study group patients was significantly higher（4.06±0.88） vs（3.20±0.53）,the data were statistically significant differences（P＆lt;0.05）.Conclusion DR in patients with prothrombotic state markers DD and FIB and vWF,ET-1 and hs-CRP compared with diabetic retinopathy high levels of clinical should pay attention to the several indicators of changes in the diagnosis and prevention of DR.in order to facilitate as a basis and prompt.
出处
《湖南中医药大学学报》
CAS
2013年第6期14-15,共2页
Journal of Hunan University of Chinese Medicine
关键词
2型糖尿病
视网膜病变
血栓前状态
标志物检测
Type 2 diabetes
Retinopathy
Prothrombotic state and flag
material detection
