摘要
目的观察丹参川芎嗪注射液治疗脑梗死后椎基底动脉供血不足(VBI)的效果及对血管内皮功能的影响。方法选取2017年8月至2019年2月本院收治的脑梗死后VBI患者80例,随机分为对照组与观察组,各40例。对照组行一般治疗,观察组在其基础上加用丹参川芎嗪注射液治疗。比较两组疗效及不良反应,观察患者血浆内皮素-1(ET-1)、血管性血友病因子(vWF)、一氧化氮(NO)水平变化。结果观察组总有效率高于对照组(P<0.05),且两组均无明显不良反应发生;治疗后两组ET-1、vWF水平降低,NO水平升高(P<0.05),且观察组较对照组改善显著(P<0.05)。结论丹参川芎嗪注射液治疗脑梗死后VBI效果良好且安全性较高,可有效改善患者血管内皮功能。
Objective To observe the effects of Danshen Chuanxiongqin injection on vertebrobasilar insufficiency (VBI) after cerebral infarction and its influence on vascular endothelial function. Methods 80 patients with VBI after cerebral infarction admitted to our hospital from August 2017 to February 2019 were randomly divided into the control group and the observation group, with 40 cases in each group. Control group was given general treatment, and observation group was additionally given Danshen Chuanxiongqin injection on this basis. The efficacy and adverse reactions were compared between the two groups. The levels of plasma endothelin-1 (ET-1), von Willebrand factor (vWF) and carbon monoxide (NO) were ob- served. Results The total effective rate in observation group was higher than that in control group (P<0.05), and there were no significant adverse reactions in the two groups. After treatment, the levels of ET-1 and vWF were decreased while the level of NO was increased in the two groups (P< 0.05), and the improvements in observation group were more significant compared with those in control group (P<0.05). Conclusion Danshen Ch- uanxiongqin injection has good effects and high safety of VBI after cerebral infarction, and it can effectively improve the vascular endothelial function of patients.
作者
徐金娥
柳志一
王音
Xu Jin’e;Liu Zhiyi;Wang Yin(Department of Neurology, Dalian Jiuzhou Century Hospital, Dalian, Liaoning, 116000, China)
出处
《当代医学》
2019年第29期15-17,共3页
Contemporary Medicine
关键词
脑梗死
椎基底动脉供血不足
丹参川穹嗪
Cerebral infarction
Vertebrobasilar insufficiency
Danshen Chuanxiongqin
